Analytical characteristics of high-sensitivity cardiac troponin assays

FS Apple, PO Collinson… - Clinical …, 2012 - academic.oup.com
Abstract BACKGROUND Cardiac troponins I (cTnI) and T (cTnT) have received international
endorsement as the standard biomarkers for detection of myocardial injury, for risk …

Cardiac troponin assays: guide to understanding analytical characteristics and their impact on clinical care

FS Apple, Y Sandoval, AS Jaffe… - Clinical …, 2017 - academic.oup.com
Abstract BACKGROUND Cardiac troponin I (cTnI) and cardiac troponin T (cTnT)
determinations are fixtures in clinical practice and research. Cardiac troponin testing has …

Evaluation of high-sensitivity assays for cardiac troponin

DA Morrow, EM Antman - Clinical chemistry, 2009 - academic.oup.com
Despite the facts that cardiac troponin was introduced 2 decades ago and has been
established since 2000 as the preferred biomarker for the diagnosis of myocardial infarction …

High-sensitivity cardiac troponin assays: From improved analytical performance to enhanced risk stratification

M Kozinski, M Krintus, J Kubica… - Critical reviews in …, 2017 - Taylor & Francis
Implementation of cardiac troponin (cTn) assays has revolutionized the diagnosis, risk
stratification, triage and management of patients with suspected myocardial infarction (MI) …

Analytical considerations in deriving 99th percentile upper reference limits for high-sensitivity cardiac troponin assays: educational recommendations from the IFCC …

KM Aakre, AK Saenger, R Body, P Collinson… - Clinical …, 2022 - academic.oup.com
Abstract The International Federation of Clinical Chemistry Committee on Clinical
Application of Cardiac Bio-Markers provides evidence-based educational documents to …

Cardiac troponin assays: a view from the clinical chemistry laboratory

SEF Melanson, MJ Tanasijevic, P Jarolim - Circulation, 2007 - Am Heart Assoc
Despite continuous advances in troponin assays, there is still significant room for
improvement, particularly in the area of assay standardization and elimination of …

Clinical relevance of biological variation of cardiac troponins

A Clerico, A Padoan, M Zaninotto… - Clinical Chemistry and …, 2021 - degruyter.com
The high-sensitivity immunoassays for cardiac troponin I (hs-cTnI) and cardiac troponin T (hs-
cTnT) are recommended by all the most recent international guidelines as gold standard …

Evaluation of analytical performance of immunoassay methods for cTnI and cTnT: From theory to practice

A Clerico, M Zaninotto, A Padoan, S Masotti… - Advances in clinical …, 2019 - Elsevier
Current guidelines worldwide recommend cardiac troponins I (cTnI) and T (cTnT) as the
biomarkers of choice for the differential diagnosis of acute coronary syndrome (ACS), and …

Troponin revisited 2008: assay performance

JR Tate - Clinical chemistry and laboratory medicine, 2008 - degruyter.com
Troponin quality specifications describing the pre-analytical, analytical and post-analytical
performance of cardiac troponin (cTn) assays are important for both manufacturers of cTn …

Standardization of troponin I measurements: an update

M Panteghini, DM Bunk, RH Christenson… - Clinical chemistry and …, 2008 - degruyter.com
Standardization of cardiac troponin I (cTnI) measurement is important because of the central
role for diagnosis of myocardial infarction. In blood, cTnI is present as a heterogeneous …