Although distinct human induced pluripotent stem cell (hiPSC) lines can display
considerable epigenetic variation, it has been unclear whether such variability impacts their …

Generating induced pluripotent stem cells (iPSCs) requires massive epigenome
reorganization. It is unclear whether reprogramming of female human cells reactivates the …

Human pluripotent stem cells (hPSCs) are potential sources of cells for modeling disease
and development, drug discovery, and regenerative medicine. However, it is important to …

Human pluripotent stem cells (hPSCs) are being increasingly utilized worldwide in
investigating human development, and modeling and discovering therapies for a wide range …

Reprogramming somatic cells to derive induced pluripotent stem cells (iPSCs) has provided
a new method to model disease and holds great promise for regenerative medicine …

Naive human embryonic stem cells (hESCs) can be derived from primed hESCs or directly
from blastocysts, but their X chromosome state has remained unresolved. Here, we show …

Human pluripotent stem cells (hPSCs) display extensive epigenetic instability, particularly
on the X chromosome. In this study, we show that, in hPSCs, the inactive X chromosome has …

Female human induced pluripotent stem cell (hiPSC) lines exhibit variability in X-inactivation
status. The majority of hiPSC lines maintain one transcriptionally active X (Xa) and one …

Generation of human induced pluripotent stem cells (hiPSCs) by the expression of specific
transcription factors depends on successful epigenetic reprogramming to a pluripotent state …

The advent of induced pluripotent stem cells (iPSCs) revolutionized human genetics by
allowing us to generate pluripotent cells from easily accessible somatic tissues. This …