In comparison to monolayer cells, MCTS has been claimed as more suitable candidate for
studying drug penetration due to the high resemblance to solid tumors. However, the …

Three dimensional multicellular aggregate, also referred to as cell spheroid or microtissue,
is an indispensable tool for in vitro evaluating antitumor activity and drug efficacy. Compared …

Multicellular tumor spheroids are widely used models in tumor research. Because of their
three dimensional organization they can simulate avascular tumor areas comprising …

In vitro 3D cancer spheroids (tumoroids) exhibit a drug resistance profile similar to that found
in solid tumors. 3D spheroid culture methods recreate more physiologically relevant …

Multicellular spheroid models have been recognized as superior to monolayer cell cultures
in antitumor drug screening, but their commercial adaptation in the pharmaceutical industry …

Background Breast cancer is the most common cause of cancer related deaths in women.
Treatment of breast cancer has many limitations including a lack of accurate biomarkers to …

Over the last few decades, the most popular platform to perform high-throughput screening
for viable anti-neoplastic compounds has been monolayer cell culture. However, cells in …

The present article highlights the rationale, potential and flexibility of tumor spheroid mono-
and cocultures for implementation into state of the art anti-cancer therapy test platforms …

Clinically relevant in vitro methods are needed to identify new cancer drugs for solid tumors.
We report on a new 3-D spheroid cell culture system aimed to mimic the properties of solid …

Spheroids are widely used in biology because they provide an in vitro 3-dimensional (3D)
model to study proliferation, cell death, differentiation, and metabolism of cells in tumors and …