Asialoerythropoietin, a nonerythropoietic derivative of erythropoietin, displays broad anti-heart failure activity

T Takeyama, G Takemura, H Kanamori… - Circulation: Heart …, 2012 - Am Heart Assoc
Background—We investigated the effects of asialoerythropoietin (asialoEPO), a
nonerythrogenic erythropoietin derivative, on 3 murine models of heart failure with different …

Erythropoietin receptor signaling mitigates renal dysfunction-associated heart failure by mechanisms unrelated to relief of anemia

A Ogino, G Takemura, M Kawasaki, A Tsujimoto… - Journal of the American …, 2010 - jacc.org
Objectives: We examined the effect of asialoerythropoietin (asialoEPO), a nonerythrogenic
derivative of erythropoietin (EPO), on renal dysfunction-associated heart failure …

Two-step purification procedure for recombinant human asialoerythropoietin expressed in transgenic plants

FS Kittur, E Arthur, M Nguyen, CY Hung… - International journal of …, 2015 - Elsevier
Asialoerythropoietin (asialo-EPO) is a desialylated form of human glycoprotein hormone
erythropoietin (EPO), which has been reported to be neuro-, cardio-, and renoprotective in …

Erythropoietin protects against doxorubicin-induced heart failure

HI Ammar, S Saba, RI Ammar… - American Journal …, 2011 - journals.physiology.org
The hormone erythropoietin (EPO) has been demonstrated to have cardioprotective
properties. The present study investigates the role of EPO to prevent heart failure following …

Asialoerythropoietin exerts stronger angiogenic activity than erythropoietin via its binding affinity to tissue

T Yanagawa, K Toba, K Kato, T Suzuki… - … drugs and therapy, 2013 - Springer
Purpose Although erythropoietin (EPO) is known to express angiogenic and cardioprotective
effects, it also induces hypertension, polycythemia, and platelet activation, which may cause …

The potential role of erythropoietin in chronic heart failure: from the correction of anemia to improved perfusion and reduced apoptosis?

SAJ Timmer, K De Boer, P Knaapen, MJW Götte… - Journal of Cardiac …, 2009 - Elsevier
Besides stimulating erythropoiesis, erythropoietin (EPO) exerts powerful proangiogenic and
antiapoptotic effects. These erythropoiesis-independent effects are potentially useful as a …

Beyond erythropoiesis: the anti-inflammatory effects of erythropoietin

Q Feng - Cardiovascular research, 2006 - academic.oup.com
Erythropoietin (EPO) is a 30.4-kDa glycoprotein essential for red blood cell production. In
adults, EPO is produced primarily in the kidney via an oxygen-sensing mechanism and …

Do non-hemopoietic effects of erythropoietin play a beneficial role in heart failure?

R Latini, M Brines, F Fiordaliso - Heart failure reviews, 2008 - Springer
Erythropoietin (EPO) is not solely a hormone charged with regulating the proliferation and
differentiation of erythroid cells. Indeed, EPO is synthesized locally by many cells, especially …

Reduction of inflammatory cytokine expression and oxidative damage by erythropoietin in chronic heart failure

Y Li, G Takemura, H Okada, S Miyata… - Cardiovascular …, 2006 - academic.oup.com
Objectives Late treatment with erythropoietin (EPO), as well as the administration before the
onset of or during the acute stage of myocardial infarction (MI), has recently been shown to …

Low‐dose erythropoietin improves cardiac function in experimental heart failure without increasing haematocrit

E Lipšic, BD Westenbrink… - European journal of …, 2008 - Wiley Online Library
Background: Erythropoietin (EPO) may improve cardiac function and induce
neovascularisation in experimental models of chronic heart failure (CHF). However, the …