Spatial and temporal organization of signal transduction is coordinated through the
segregation of signaling enzymes in selected cellular compartments. This highly evolved …

The cAMP-dependent kinase (PKA) is a broad specificity kinase that controls several
fundamental processes in the heart including the strength and the frequency of contraction …

A fundamental role for protein–protein interactions in the organization of signal transduction
pathways is evident. Anchoring, scaffolding and adapter proteins function to enhance the …

Downstream regulation of the cAMP-dependent protein kinase (PKA) pathway is mediated
by anchoring proteins (AKAPs) that sequester PKA to specific subcellular locations through …

The cAMP-dependent protein kinase (PKA) transduces signals in the heart initiated by β1-
adrenergic, G-protein-coupled receptors after norepinephrine, sympathetic stimulation …

The pleiotropic cyclic nucleotide cAMP is the primary second messenger responsible for
autonomic regulation of cardiac inotropy, chronotropy, and lusitropy. Under conditions of …

Compartmentalization of kinases and phosphatases is a key determinant in the specificity of
second messenger mediated signaling events. Localization of the cAMP-dependent protein …

The cAMP-dependent protein kinase A (PKA) is targeted to specific compartments in the
cardiac myocyte by A-kinase anchoring proteins (AKAPs), a diverse set of scaffold proteins …

A‐kinase anchoring proteins (AKAPs) crucially contribute to the spatial and temporal control
of cellular signalling. They directly interact with a variety of protein binding partners and …

cAMP-dependent protein kinase is targeted to discrete subcellular locations by a family of
specific anchor proteins (A-kinase anchor proteins, AKAPs). Localization recruits protein …