Evasion of apoptosis is one of the crucial acquired capabilities used by cancer cells to fend
off anticancer therapies. Inhibitor of apoptosis (IAP) proteins exert a range of biological …

The inhibitors of apoptosis (IAPs) constitute a family of proteins involved in the regulation of
various cellular processes, including cell death, immune and inflammatory responses, cell …

Inhibitor of apoptosis (IAP) proteins play a critical role in the control of survival and cell death
by regulating key signaling events such as caspase activation and NF-κB signaling …

Apoptosis has been accepted as a fundamental component in the pathogenesis of cancer,
in addition to other human diseases including neurodegeneration, coronary disease and …

Apoptosis, an important form of programmed cell death (PCD), is a tightly regulated cellular
process to eliminate unwanted or damaged cells. Resistance of apoptosis is a hallmark of …

Cell death regulation is vital for maintenance of homeostasis and proper development of
multicellular organisms. Inhibitor of apoptosis (IAP) proteins are implicated in multiple ways …

Apoptosis is a cell suicide process with a major role in development and homeostasis in
vertebrates and invertebrates. Inhibition of apoptosis enhances the survival of cancer cells …

Inhibitor of apoptosis (IAP) family comprises a group of endogenous proteins that function as
main regulators of caspase activity and cell death. They are considered the main culprits in …

A promising strategy in cancer therapy aims to promote apoptosis in cancer cells. Targeting
inhibitor of apoptosis proteins (IAPs) with small-molecule inhibitors has attracted increasing …

Recent studies have shown that members of the inhibitor of apoptosis (IAP) protein family
are highly expressed in several classes of cancer. The primary implication of these findings …