The potential benefits of gene therapy for neurological diseases such as Parkinson's,
Amyotrophic Lateral Sclerosis (ALS), Epilepsy, and Alzheimer's are enormous. Even a delay …

Our ability to manipulate the genetic constitution of the nervous system has come of age with
various technologies, including virus vectors that can efficiently deliver genes to neurons …

Gene transfer is an increasingly utilized approach for research and clinical applications
involving the central nervous system (CNS). Vectors for gene transfer can be as simple as …

The postgenomic era has been ushered in making promises for cures and functional
analysis of previously unknown or uncharacterized genes. However, realization of the …

The efficient delivery of therapeutic genes and appropriate gene expression are the crucial
issues for clinically relevant gene therapy. Viruses are naturally evolved vehicles which …

Gene therapy is now being applied to the treatment of a wide variety of acquired and
inherited diseases. One of the rate-limiting steps for successful gene therapy is the efficiency …

In the late 1970s, it was predicted that gene therapy would be applied to humans within a
decade. However, despite some success, gene therapy has still not become a routine …

The success of current and future gene therapy approaches is largely dependent upon the
vector systems used to carry the therapeutic genes. Issues of efficiency, specificity and safety …

Diseases of the central nervous system (CNS) have traditionally been the most difficult to
treat by traditional pharmacological methods, due mostly to the blood–brain barrier and the …

Current clinical treatments for central nervous system (CNS) diseases, such as Parkinson's
disease and glioblastoma do not halt disease progression and have significant treatment …