Lethal, hereditary mutants of phospholamban elude phosphorylation by protein kinase A
DK Ceholski, CA Trieber, CFB Holmes… - Journal of Biological …, 2012 - ASBMB
The sarcoplasmic reticulum calcium pump (SERCA) and its regulator, phospholamban, are
essential components of cardiac contractility. Phospholamban modulates contractility by …
essential components of cardiac contractility. Phospholamban modulates contractility by …
Phosphorylation and mutation of phospholamban alter physical interactions with the sarcoplasmic reticulum calcium pump
JP Glaves, CA Trieber, DK Ceholski, DL Stokes… - Journal of molecular …, 2011 - Elsevier
Phospholamban physically interacts with the sarcoplasmic reticulum calcium pump
(SERCA) and regulates contractility of the heart in response to adrenergic stimuli. We …
(SERCA) and regulates contractility of the heart in response to adrenergic stimuli. We …
Deception in simplicity: hereditary phospholamban mutations in dilated cardiomyopathy
HS Young, DK Ceholski… - Biochemistry and Cell …, 2015 - cdnsciencepub.com
The sarcoplasmic reticulum (SR) calcium pump (SERCA) and its regulator phospholamban
are required for cardiovascular function. Phospholamban alters the apparent calcium affinity …
are required for cardiovascular function. Phospholamban alters the apparent calcium affinity …
Transgenic approaches to define the functional role of dual site phospholamban phosphorylation
W Luo, G Chu, Y Sato, Z Zhou, VJ Kadambi… - Journal of Biological …, 1998 - ASBMB
Phospholamban is a critical regulator of the sarcoplasmic reticulum Ca 2+-ATPase activity
and myocardial contractility. Phosphorylation of phospholamban occurs on both Ser 16 and …
and myocardial contractility. Phosphorylation of phospholamban occurs on both Ser 16 and …
Phospholamban binds with differential affinity to calcium pump conformers
P Bidwell, DJ Blackwell, Z Hou, AV Zima… - Journal of Biological …, 2011 - ASBMB
To investigate the mechanism of regulation of sarco-endoplasmic reticulum Ca 2+-ATPase
(SERCA) by phospholamban (PLB), we expressed Cerulean-SERCA and yellow fluorescent …
(SERCA) by phospholamban (PLB), we expressed Cerulean-SERCA and yellow fluorescent …
Allosteric regulation of SERCA by phosphorylation-mediated conformational shift of phospholamban
M Gustavsson, R Verardi, DG Mullen… - Proceedings of the …, 2013 - National Acad Sciences
The membrane protein complex between the sarcoplasmic reticulum Ca2+-ATPase
(SERCA) and phospholamban (PLN) controls Ca2+ transport in cardiomyocytes, thereby …
(SERCA) and phospholamban (PLN) controls Ca2+ transport in cardiomyocytes, thereby …
Cross-linking of C-terminal residues of phospholamban to the Ca2+ pump of cardiac sarcoplasmic reticulum to probe spatial and functional interactions within the …
Z Chen, BL Akin, DL Stokes, LR Jones - Journal of Biological Chemistry, 2006 - ASBMB
Interactions between the transmembrane domains of phospholamban (PLB) and the cardiac
Ca 2+ pump (SERCA2a) have been investigated by chemical cross-linking. Specifically, C …
Ca 2+ pump (SERCA2a) have been investigated by chemical cross-linking. Specifically, C …
Phospholamban and cardiac contractility
K Frank, EG Kranias - Annals of medicine, 2000 - Taylor & Francis
Over the last three decades, our knowledge and understanding of the role of
phospholamban and its modulation of sarcoplasmic reticulum (SR) function has advanced …
phospholamban and its modulation of sarcoplasmic reticulum (SR) function has advanced …
Phospholamban phosphorylation, mutation, and structural dynamics: a biophysical approach to understanding and treating cardiomyopathy
NAD Ablorh, DD Thomas - Biophysical reviews, 2015 - Springer
We review the recent development of novel biochemical and spectroscopic methods to
determine the site-specific phosphorylation, expression, mutation, and structural dynamics of …
determine the site-specific phosphorylation, expression, mutation, and structural dynamics of …
Cardiac-specific overexpression of a superinhibitory pentameric phospholamban mutant enhances inhibition of cardiac functionin vivo
J Zhai, AG Schmidt, BD Hoit, Y Kimura… - Journal of Biological …, 2000 - ASBMB
Phospholamban is a regulator of the Ca 2+ affinity of the cardiac sarcoplasmic reticulum Ca
2+ ATPase (SERCA2a) and of cardiac contractility. In vitro expression studies have shown …
2+ ATPase (SERCA2a) and of cardiac contractility. In vitro expression studies have shown …