Background The multicellular tumor spheroid (MCTS) is an in vitro model associating
malignant-cell microenvironment and 3D organization as currently observed in avascular …

Abstract Background MultiCellular Tumor Spheroid (MCTS) mimics the organization of a
tumor and is considered as an invaluable model to study cancer cell biology and to evaluate …

A clear contradiction exists between cytotoxic in-vitro studies demonstrating effectiveness of
Gemcitabine to curtail pancreatic cancer and in-vivo studies failing to show Gemcitabine as …

Simple Summary Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive
cancers, with a five-year survival rate of less than 8%. There is a need to develop drugs with …

MultiCellular Tumor Spheroids (MCTS), which mimic the 3-Dimensional (3D) organization of
a tumor, are considered as better models than conventional cultures in 2-Dimensions (2D) to …

Introduction: For the past 30 years 2D-cell-based assay models have dominated preclinical
cancer drug discovery efforts. 2D-cell-based models fail to predict in vivo efficacy …

Background Pancreatic ductal adenocarcinoma (PDAC) is a stroma-rich carcinoma, and
pancreatic stellate cells (PSCs) are a major component of this dense stroma. PSCs play …

Simple Summary Pancreatic cancer is an extremely lethal malignancy with a survival rate
lower than any other cancer type. For decades, two-dimensional (2D) cultures have been …

Abstract The three-dimensional (3D) multicellular tumor spheroids (MCTs) model is
becoming an essential tool in cancer research as it expresses an intermediate complexity …

A recent decline in the discovery of novel medications challenges the widespread use of 2D
monolayer cell assays in the drug discovery process. As a result, the need for more …