Most chronic diseases—such as cancer, cardiovascular disease (CVD), Alzheimer disease,
Parkinson disease, arthritis, diabetes and obesity—are becoming leading causes of …

Abstract The National Institutes of Health (NIH) Geroscience Interest Group (GSIG)
sponsored workshop, The Role of Inflammation in Age-Related Disease, was held …

Cytokine dysregulation is believed to play a key role in the remodeling of the immune
system at older age, with evidence pointing to an inability to fine-control systemic …

Recent scientific studies have advanced the notion of chronic inflammation as a major risk
factor underlying aging and age-related diseases. In this review, low-grade, unresolved …

Biological aging is characterized by a chronic low-grade inflammation level. This chronic
phenomenon has been named “inflamm-aging” and is a highly significant risk factor for …

Highlights•Elderly people commonly show signs of low level systemic inflammation.•Causes
include presence of senescent cells, chronic infections and obesity.•Systemic inflammation …

The last 10 y have seen an enormous surge in research focused on inflammation and
atherosclerotic heart disease. In parallel, inflammation (used as a term to represent a broad …

Nowadays, people are living much longer than they used to do, however they are not free
from ageing. Ageing, an inexorable intrinsic process that affects all cells, tissues, organs and …

The aging process is driven by multiple mechanisms that lead to changes in energy
production, oxidative stress, homeostatic dysregulation and eventually to loss of functionality …

Increasing evidence from diverse sources during the past several years has indicated that
long-term, low level, chronic inflammation mediates several chronic diseases including …