Therapeutic approach to neurodegenerative diseases by medical gases: focusing on redox signaling and related antioxidant enzymes

K Fujita, M Yamafuji, Y Nakabeppu… - Oxidative medicine and …, 2012 - Wiley Online Library
Oxidative stress in the central nervous system is strongly associated with neuronal cell death
in the pathogenesis of several neurodegenerative diseases such as Alzheimer′ s disease …

Oxidative stress and neurodegenerative diseases: a review of upstream and downstream antioxidant therapeutic options

B Uttara, AV Singh, P Zamboni… - Current …, 2009 - ingentaconnect.com
Free radicals are common outcome of normal aerobic cellular metabolism. In-built
antioxidant system of body plays its decisive role in prevention of any loss due to free …

The role of oxidative stress in neurodegenerative diseases and potential antioxidant therapies

PS Bailo, EL Martín, P Calmarza, SM Breva… - Advances in laboratory …, 2022 - degruyter.com
Objectives: The central nervous system (CNS) is essential for homeostasis and controls the
physiological functions of the body. However, the biochemical characteristics of the CNS …

Free radical biology in neurological manifestations: mechanisms to therapeutics interventions

R Tripathi, R Gupta, M Sahu, D Srivastava… - … Science and Pollution …, 2021 - Springer
Recent advancements and growing attention about free radicals (ROS) and redox signaling
enable the scientific fraternity to consider their involvement in the pathophysiology of …

Role of gasotransmitters in oxidative stresses, neuroinflammation, and neuronal repair

U Shefa, SG Yeo, MS Kim, IO Song… - BioMed Research …, 2017 - Wiley Online Library
To date, three main gasotransmitters, that is, hydrogen sulfide (H2S), carbon monoxide
(CO), and nitric oxide (NO), have been discovered to play major bodily physiological roles …

Oxidative stress in neurodegenerative diseases: From preclinical studies to clinical applications

A Tarozzi - Journal of Clinical Medicine, 2020 - mdpi.com
Oxidative stress plays an important role in the pathogenesis of several different
neurodegenerative diseases (NDDs), such as Alzheimer's disease (AD), Parkinson's …

Neurodegenerative diseases and oxidative stress

J Emerit, M Edeas, F Bricaire - Biomedicine & pharmacotherapy, 2004 - Elsevier
Oxidative stress is now recognized as accountable for redox regulation involving reactive
oxygen species (ROS) and reactive nitrogen species (RNS). Its role is pivotal for the …

Dual effects of antioxidants in neurodegeneration: direct neuroprotection against oxidative stress and indirect protection via suppression of gliamediated inflammation

JY Wang, LL Wen, YN Huang… - Current …, 2006 - ingentaconnect.com
Oxidative stress, in which production of highly reactive oxygen species (ROS) and reactive
nitrogen species (RNS) overwhelms antioxidant defenses, is a feature of many neurological …

The underlying role of oxidative stress in neurodegeneration: a mechanistic review

H Yaribeygi, Y Panahi, B Javadi… - CNS & Neurological …, 2018 - ingentaconnect.com
Background: Neurodegeneration is a condition in which progressive loss of function and
structure of neurons occurs. Several lines of evidence suggest that oxidative stress has a …

Oxidative stress in neurodegenerative diseases: mechanisms and therapeutic perspectives

A Melo, L Monteiro, RMF Lima… - Oxidative medicine …, 2011 - Wiley Online Library
The incidence and prevalence of neurodegenerative diseases (ND) increase with life
expectancy. This paper reviews the role of oxidative stress (OS) in ND and pharmacological …