増加し, 胞体突起形成巨核球の platelet bud 及び血小板においても Bcl-xL タンパクの発現は確認
されること, また抗血小板抗体を投与した血小板減少モデルマウスにおいても, 血小板回復期に至る …

Abstract Abstract 1495 Poster Board I-518 Recent studies have suggested a role for the
intrinsic apoptosis pathway in megakaryocytic differentiation and platelet shedding. The …

OBJECTIVE: The expression of Bcl-xL has been shown to be regulated during the
maturation process of different hematopoietic cell lineages (ie, erythroid cells, neutrophils …

Fragmentation of polyploid megakaryocytes into platelets has great relevance for blood
homeostasis. Apoptotic cell death is a highly regulated genetic program, which has been …

Background: One of the important biological activities of thrombopoietin (TPO) is to prevent
the apoptosis of megakaryocytes. As the antiapoptotic protein Bcl‐xL, which has been …

Megakaryocyte differentiation and fragmentation into platelets is associated with apoptosis.
In these studies we sought to determine whether apoptosis is required for normal …

Abstract 550 It is widely held that megakaryocytes undergo a specialized form of apoptosis
in order to shed platelets. Conversely, it is also believed that a range of insults including …

This study was conducted to elucidate the anti-apoptotic mechanism operating during
differentiation of megakaryocytes (Mgks) from hematopoietic stem cells. As previous reports …

Genome-wide mutagenesis (so-called “forward genetics”) has been used widely in non-
vertebral model systems (including flies, worms, yeast, and bacteria) to discover pathways …

BACKGROUND AND OBJECTIVES: Essential thrombocythemia (ET) is a chronic
myeloproliferative disorder with abnormal megakaryocyte/platelet production. Recent …