This study was aimed to characterize the human endoplasmic reticulum (ER) translocase at
the cellular level in terms of its functions and regulatory mechanisms. The attention has been …

In yeast, efficient protein transport across the endoplasmic reticulum (ER) membrane may
occur co-translationally or post-translationally. The latter process is mediated by a …

Sec24 of the COPII (coat protein complex II) vesicle coat mediates the selective export of
membrane proteins from the endoplasmic reticulum (ER) in yeast. Human cells express four …

In human cells, the endoplasmic reticulum (ER) is central to protein biogenesis and Ca 2+
homeostasis. Protein biogenesis requires an aqueous polypeptide-conducting channel in …

The heterotrimeric Sec61 protein complex forms the functional core of the so-called
translocon that forms an aqueous channel in the endoplasmic reticulum (ER). The primary …

Sss1p, an essential component of the heterotrimeric Sec61 complex in the ER (endoplasmic
reticulum), is a tail-anchored protein whose precise mechanism of action is largely unknown …

The Sec61 complex performs a dual function in protein translocation across the RER,
serving as both the high affinity ribosome receptor and the translocation channel. To define …

Budding yeast Sec16 is a large peripheral endoplasmic reticulum (ER) membrane protein
that functions in generating COPII transport vesicles and in clustering COPII components at …

The Sec61 translocon of the endoplasmic reticulum (ER) membrane forms an aqueous pore,
allowing polypeptides to be transferred across or integrated into membranes. Protein …

The rough endoplasmic reticulum (ER) of nucleated human cells has crucial functions in
protein biogenesis, calcium (Ca2+) homeostasis, and signal transduction. Among the …