We have extensively characterized the DNA methylomes of 139 patients with chronic
lymphocytic leukemia (CLL) with mutated or unmutated IGHV and of several mature B-cell …

We conducted a genome-wide DNA methylation analysis in CD19+ B-cells from chronic
lymphocytic leukemia (CLL) patients and normal control samples using reduced …

We performed a genome-wide analysis of aberrant DNA methylation in chronic lymphocytic
leukemia (CLL) using methylated CpG island amplification (MCA) coupled with a promoter …

Charting differences between tumors and normal tissue is a mainstay of cancer research.
However, clonal tumor expansion from complex normal tissue architectures potentially …

Genetic and epigenetic intra-tumoral heterogeneity cooperate to shape the evolutionary
course of cancer. Chronic lymphocytic leukaemia (CLL) is a highly informative model for …

Although clonal selection by genetic driver aberrations in cancer is well documented, the
ability of epigenetic alterations to promote tumor evolution is undefined. We used 450k …

DNA methylation is associated with malignant transformation, but limitations imposed by
genetic variability, tumor heterogeneity, availability of paired normal tissues and …

DNA methylation is tightly regulated during development and is stably maintained in healthy
cells. In contrast, cancer cells are commonly characterized by a global loss of DNA …

In chronic lymphocytic leukemia (CLL), the microenvironment influences gene expression
patterns; however, knowledge is limited regarding the extent to which methylation changes …

The clinical heterogeneity that characterizes chronic lymphocytic leukemia (CLL), with
survival times ranging from months to decades, reflects its biological diversity. Our …