Studies using high-resolution genome-wide approaches have recently reported that
genomic and epigenomic alterations frequently accumulate in human pluripotent cells …

The usefulness of human induced pluripotent stem cells (hiPSCs) in research and
therapeutic applications highly relies on their genomic integrity and stability. Many …

Pluripotent stem cells may acquire genetic and epigenetic variants during culture following
their derivation. At a conference organized by the International Stem Cell Initiative, and held …

Human pluripotent stem cells (hPSCs) are known to acquire genomic changes as they
proliferate and differentiate. Despite concerns that these changes will compromise the safety …

Human embryonic stem cells (hESCs) share an identical genome with lineage-committed
cells, yet possess the remarkable properties of self-renewal and pluripotency. The diverse …

Evaluation of the extent and nature of induced pluripotent stem cell (iPSC) genetic instability
is important for both basic research and future clinical use. As previously demonstrated …

Pluripotent stem cells constitute a platform to model disease and developmental processes
and can potentially be used in regenerative medicine. However, not all pluripotent cell lines …

Pluripotent stem cells (PSCs) must maintain their proper genomic content in order to
preserve appropriate self-renewal and differentiation capacities. However, their prolonged in …

While there are a growing number of human pluripotent stem cell repositories, genetic
diversity remains limited in most collections and studies. Here, we discuss the importance of …

The potential of human induced pluripotent stem cells (iPSCs) to self-renew indefinitely and
to differentiate virtually into any cell type in unlimited quantities makes them attractive for in …