Distinct DNA methylomes of newborns and centenarians
Human aging cannot be fully understood in terms of the constrained genetic setting.
Epigenetic drift is an alternative means of explaining age-associated alterations. To address …
Epigenetic drift is an alternative means of explaining age-associated alterations. To address …
Role of epigenetics in human aging and longevity: genome-wide DNA methylation profile in centenarians and centenarians' offspring
The role of epigenetics in the modulation of longevity has not been studied in humans. To
this aim,(1) we evaluated the DNA methylation from peripheral leukocytes of 21 female …
this aim,(1) we evaluated the DNA methylation from peripheral leukocytes of 21 female …
A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects
The central importance of epigenetics to the aging process is increasingly being recognized.
Here we perform a methylome-wide association study (MWAS) of aging in whole blood DNA …
Here we perform a methylome-wide association study (MWAS) of aging in whole blood DNA …
Epigenetic profiling of somatic tissues from human autopsy specimens identifies tissue-and individual-specific DNA methylation patterns
HM Byun, KD Siegmund, F Pan… - Human molecular …, 2009 - academic.oup.com
DNA methylation is known to be associated with cell differentiation, aging, disease and
cancer. There exists an expanding base of knowledge regarding tissue-specific DNA …
cancer. There exists an expanding base of knowledge regarding tissue-specific DNA …
H3K4me1 marks DNA regions hypomethylated during aging in human stem and differentiated cells
AF Fernández, GF Bayón, RG Urdinguio… - Genome …, 2015 - genome.cshlp.org
In differentiated cells, aging is associated with hypermethylation of DNA regions enriched in
repressive histone post-translational modifications. However, the chromatin marks …
repressive histone post-translational modifications. However, the chromatin marks …
Ageing-associated changes in the human DNA methylome: genomic locations and effects on gene expression
S Marttila, L Kananen, S Häyrynen, J Jylhävä… - BMC genomics, 2015 - Springer
Background Changes in DNA methylation are among the mechanisms contributing to the
ageing process. We sought to identify ageing-associated DNA methylation changes at …
ageing process. We sought to identify ageing-associated DNA methylation changes at …
Continuous aging of the human DNA methylome throughout the human lifespan
Å Johansson, S Enroth, U Gyllensten - PloS one, 2013 - journals.plos.org
DNA methylation plays an important role in development of disease and the process of
aging. In this study we examine DNA methylation at 476,366 sites throughout the genome of …
aging. In this study we examine DNA methylation at 476,366 sites throughout the genome of …
Parental ages and levels of DNA methylation in the newborn are correlated
RM Adkins, F Thomas, FA Tylavsky, J Krushkal - BMC medical genetics, 2011 - Springer
Background Changes in DNA methylation patterns with age frequently have been observed
and implicated in the normal aging process and its associated increasing risk of disease …
and implicated in the normal aging process and its associated increasing risk of disease …
DNA methylation analysis techniques
C Dahl, P Guldberg - Biogerontology, 2003 - Springer
DNA methylation contributes to the control of gene expression and plays an essential role in
cellular physiology. Well-defined patterns of DNA methylation are established and fixed …
cellular physiology. Well-defined patterns of DNA methylation are established and fixed …
Distinct DNA methylation changes highly correlated with chronological age in the human brain
Methylation at CpG sites is a critical epigenetic modification in mammals. Altered DNA
methylation has been suggested to be a central mechanism in development, some disease …
methylation has been suggested to be a central mechanism in development, some disease …