Cancer stem cell research is one of the most thriving and competitive areas in oncology
research because it has the potential to dramatically affect clinical outcomes. Led by …

Radiotherapy has a proven potential to eradicate cancer stem cells which is reflected by its
curative potential in many cancer types. Considerable progress has been made in …

Purpose: The present work summarises the history and current status of research into the
importance of cancer stem cells for radiobiological research and for clinical radiation …

Purpose: Despite technological improvement and advances in biology-driven patient
stratification, many patients still fail radiotherapy resulting in loco-regional and distant …

Despite continuous improvements in cancer management, locoregional recurrence or
metastatic spread still occurs in a high proportion of patients after radiotherapy or combined …

Since the first prospective identification of cancer stem cells in solid cancers the cancer stem
cell hypothesis has reemerged as a research topic of increasing interest. It postulates that …

Cancer stem cells (CSC) have the unique ability to cause tumor recurrences if they survive
treatment. Radiotherapy has curative potential because it has been functionally shown to …

A growing body of evidence indicates that subpopulations of cancer stem cells (CSCs) drive
and maintain many types of human malignancies. These findings have important …

Purpose: Tumours are composed of a heterogeneous cell population. Cancer stem cells,
which make up a minor fraction of a tumour, may be the cells that initiate and sustain tumour …

Normal tissues are organized hierarchically with a small number of stem cells, able to self-
renew and give rise to all the differentiated cells found in the respective specialized tissues …