IGFBP3 impedes aggressive growth of pediatric liver cancer and is epigenetically silenced in vascular invasive and metastatic tumors

I Regel, M Eichenmüller, S Joppien, J Liebl, B Häberle… - Molecular cancer, 2012 - Springer
Background Hepatoblastoma (HB) is an embryonal liver neoplasm of early childhood with a
poor prognosis for patients with distant metastases and vascular invasion. We and others …

Epigenetic silencing of IGFBPL1 promotes esophageal cancer growth by activating PI3K-AKT signaling

Y Liu, M Zhang, T He, W Yang, L Wang, L Zhang… - Clinical …, 2020 - Springer
Background There are seven insulin-like growth factor binding proteins (IGFBPs) that bind
insulin-like growth factors (IGFs). IGFBP like protein1 (IGFBPL1) is a new member of this …

IGFBP7 plays a potential tumor suppressor role against colorectal carcinogenesis with its expression associated with DNA hypomethylation of exon 1

W Ruan, J Lin, E Xu, F Xu, Y Ma, H Deng… - Journal of Zhejiang …, 2006 - Springer
Insulin-like growth factor binding-protein-7 (IGFBP7) was obtained from our previous colonic
adenocarcinoma (CRC) and normal mucosa suppression subtraction hybridization (SSH) …

Decreased expression of IGFBP6 correlates with poor survival in colorectal cancer patients

C Zhao, X Zhu, G Wang, W Wang, S Ju… - Pathology-Research and …, 2020 - Elsevier
Background The insulin-like growth factor binding protein 6 (IGFBP6), as a specific inhibitor
of IGF-Ⅱ, is a candidate human anti-oncogene in multiple tumors. However, the expression …

Functional promoter upstream p53 regulatory sequence of IGFBP3 that is silenced by tumor specific methylation

T Hanafusa, T Shinji, H Shiraha, K Nouso, Y Iwasaki… - BMC cancer, 2005 - Springer
Background Insulin-like growth factor binding protein (IGFBP)-3 functions as a carrier of
insulin-like growth factors (IGFs) in circulation and a mediator of the growth suppression …

[HTML][HTML] High IGFBP2 expression correlates with tumor severity in pediatric rhabdomyosarcoma

L Tombolan, F Orso, V Guzzardo, S Casara… - The American journal of …, 2011 - Elsevier
Rhabdomyosarcoma (RMS) is the most common childhood sarcoma and is identified as
either the embryonal or alveolar (ARMS) subtype. In approximately 75% of cases, ARMSs …

IGFBP2 in cancer: Pathological role and clinical significance

LF Wei, XF Weng, XC Huang, YH Peng… - Oncology …, 2021 - spandidos-publications.com
The versatility of IGFBP2, as a secreted protein in cancer cells or a cytoplasmic signaling
effector, has been extensively investigated in many malignant cancers. Over the last few …

[HTML][HTML] IGFBP3 inhibits tumor growth and invasion of lung cancer cells and is associated with improved survival in lung cancer patients

H Kuhn, A Frille, MA Petersen, J Oberhuber-Kurth… - Translational …, 2023 - Elsevier
The insulin-like growth factor (IGF)-pathway is involved in tumor cell proliferation,
metastasis, and survival. We aimed to find out what effects IGF binding protein 3 (IGFBP3) …

Methylation patterns of IGFBP7 in colon cancer cell lines are associated with levels of gene expression

J Lin, M Lai, Q Huang, Y Ma, J Cui… - The Journal of …, 2007 - Wiley Online Library
Altered expression of insulin‐like growth factor binding protein 7 (IGFBP7) has been found
in colon cancer, but the exact regulatory mechanism has not been fully investigated. In order …

Reactivation of IGFBP7 by DNA demethylation inhibits human colon cancer cell growth in vitro

J Lin, M Lai, Q Huang, W Ruan, Y Ma… - Cancer biology & …, 2008 - Taylor & Francis
Background: The insulin-like growth factor binding protein 7 (IGFBP7) gene is regulated by
DNA methylation in colon cancer, which was identified in our previous study. In this study …