Abstract Loss of calcium (Ca2+) homeostasis contributes through different mechanisms to
cell death occurring during the first minutes of reperfusion. One of them is an unregulated …

Calpains are ubiquitous non-lysosomal Ca 2+-dependent cysteine proteases also present in
myocardial cytosol and mitochondria. Numerous experimental studies reveal an essential …

Calpains contribute to reperfusion-induced myocardial cell death. However, it remains
controversial whether its activation occurs during ischemia or reperfusion. We investigated …

Cardiac pathology, such as myocardial infarction (MI), activates intracellular proteases that
often trigger programmed cell death and contribute to maladaptive changes in myocardial …

The calpains have been proposed to be activated following cardiac ischaemia and to
contribute to myocyte damage after myocardial infarction (MI). In this study, the activity of …

Calpains, a family of Ca2+-dependent cysteine proteases, are activated during myocardial
ischemia and reperfusion. This study investigates the cardioprotective effects of calpain …

Regulating the balance between synthesis and proteasomal degradation of cellular proteins
is essential for tissue growth and maintenance, but the critical pathways regulating protein …

Calpains make up a family of Ca 2+-dependent intracellular cysteine proteases that include
ubiquitously expressed μ-and m-calpains. Both are heterodimers consisting of a distinct …

The Ca2+-activated protease calpain has been shown to play a deleterious role in the heart
during ischemia-reperfusion (I/R). We tested the hypothesis that exercise training would …

Calpains are cytosolic calcium-activated cysteine proteases. Recently, they have been
proposed to influence signal transduction processes leading to myocardial remodelling and …