The multidimensional role of calcium in atrial fibrillation pathophysiology: mechanistic insights and therapeutic opportunities
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia, and its prevalence is
increasing with the ageing of the population. Presently available treatment options are far …
increasing with the ageing of the population. Presently available treatment options are far …
Alterations of atrial Ca2+ handling as cause and consequence of atrial fibrillation
M Greiser, WJ Lederer, U Schotten - Cardiovascular research, 2011 - academic.oup.com
Atrial fibrillation (AF) is the most prevalent sustained arrhythmia. As the most important risk
factor for embolic stroke, AF is associated with a high morbidity and mortality. Despite …
factor for embolic stroke, AF is associated with a high morbidity and mortality. Despite …
Dynamic remodeling of intracellular Ca2+ signaling during atrial fibrillation
M Greiser, U Schotten - Journal of molecular and cellular cardiology, 2013 - Elsevier
During atrial fibrillation (AF) intracellular Ca2+ signaling in atrial myocytes changes
substantially. This 'remodeled'intracellular Ca2+ homeostasis plays an important role in the …
substantially. This 'remodeled'intracellular Ca2+ homeostasis plays an important role in the …
Calcium handling abnormalities in atrial fibrillation as a target for innovative therapeutics
Atrial electrical and structural alterations (remodeling) have emerged as key elements in the
development of the atrial fibrillation (AF) substrate. Evidence points to abnormalities in …
development of the atrial fibrillation (AF) substrate. Evidence points to abnormalities in …
[HTML][HTML] Calcium in the pathophysiology of atrial fibrillation and heart failure
NC Denham, CM Pearman, JL Caldwell… - Frontiers in …, 2018 - frontiersin.org
Atrial fibrillation (AF) is commonly associated with heart failure. A bidirectional relationship
exists between the two—AF exacerbates heart failure causing a significant increase in heart …
exists between the two—AF exacerbates heart failure causing a significant increase in heart …
[HTML][HTML] Calcium dysregulation in atrial fibrillation: the role of CaMKII
Atrial fibrillation (AF) is the most frequently encountered clinical arrhythmia and is associated
with increased morbidity and mortality. Ectopic activity and reentry are considered major …
with increased morbidity and mortality. Ectopic activity and reentry are considered major …
Cellular and molecular electrophysiology of atrial fibrillation initiation, maintenance, and progression
Atrial fibrillation (AF) is the most common clinically relevant arrhythmia and is associated
with increased morbidity and mortality. The incidence of AF is expected to continue to rise …
with increased morbidity and mortality. The incidence of AF is expected to continue to rise …
Computational models of atrial cellular electrophysiology and calcium handling, and their role in atrial fibrillation
The complexity of the heart makes an intuitive understanding of the relative contribution of
ion channels, transporters and signalling pathways to cardiac electrophysiology …
ion channels, transporters and signalling pathways to cardiac electrophysiology …
Ionic Determinants of Atrial Fibrillation and Ca2+ Channel Abnormalities: Cause, Consequence, or Innocent Bystander?
S Nattel - Circulation research, 1999 - Am Heart Assoc
Over the past several years, there has been increasing interest in understanding the basic
mechanisms underlying atrial fibrillation (AF). The rise in interest is partly related to the …
mechanisms underlying atrial fibrillation (AF). The rise in interest is partly related to the …
Cellular signaling underlying atrial tachycardia remodeling of L-type calcium current
Atrial tachycardia (AT) downregulates L-type Ca2+ current (I CaL) and causes atrial
fibrillation–promoting electric remodeling. This study assessed potential underlying signal …
fibrillation–promoting electric remodeling. This study assessed potential underlying signal …
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