First appearance and location of catecholaminergic cells during experimental arthritis and elimination by chemical sympathectomy
S Capellino, K Weber, M Gelder, P Härle… - Arthritis & …, 2012 - Wiley Online Library
Objective The sympathetic nervous system is proinflammatory in early collagen‐induced
arthritis (CIA) and antiinflammatory in late disease. In late arthritis, sympathetic innervation of …
arthritis (CIA) and antiinflammatory in late disease. In late arthritis, sympathetic innervation of …
Catecholamine-producing cells in the synovial tissue during arthritis: modulation of sympathetic neurotransmitters as new therapeutic target
S Capellino, M Cosentino, C Wolff, M Schmidt… - Annals of the …, 2010 - ard.bmj.com
Background The proinflammatory and anti-inflammatory role of the sympathetic nervous
system in early and late inflammation is an unresolved paradox. A drastic loss of …
system in early and late inflammation is an unresolved paradox. A drastic loss of …
[HTML][HTML] Components of the sympathetic nervous system as targets to modulate inflammation–rheumatoid arthritis synovial fibroblasts as neuron-like cells?
X Cheng, T Lowin, N Honke, G Pongratz - Journal of Inflammation, 2023 - Springer
Background Catecholamines are major neurotransmitters of the sympathetic nervous system
(SNS) and they are of pivotal importance in regulating numerous physiological and …
(SNS) and they are of pivotal importance in regulating numerous physiological and …
An early sympathetic nervous system influence exacerbates collagen‐induced arthritis via CD4+ CD25+ cells
P Härle, G Pongratz, J Albrecht… - … : Official Journal of …, 2008 - Wiley Online Library
Objective Activation of the sympathetic nervous system (SNS) ameliorates collagen‐induced
arthritis (CIA) in the late phase of the disease but aggravates it in the presymptomatic phase …
arthritis (CIA) in the late phase of the disease but aggravates it in the presymptomatic phase …
Norepinephrine from synovial tyrosine hydroxylase positive cells is a strong indicator of synovial inflammation in rheumatoid arthritis.
LE Miller, J Grifka, J Schölmerich… - The Journal of …, 2002 - jrheum.org
OBJECTIVE: Density of sympathetic nerve fibers in synovial tissue was lower in patients with
rheumatoid arthritis (RA) compared to those with osteoarthritis (OA). This was accompanied …
rheumatoid arthritis (RA) compared to those with osteoarthritis (OA). This was accompanied …
Anti-inflammatory effects of cell-based therapy with tyrosine hydroxylase-positive catecholaminergic cells in experimental arthritis
Z Jenei-Lanzl, S Capellino, F Kees, M Fleck… - Annals of the …, 2015 - ard.bmj.com
Objectives Studies in rheumatoid arthritis (RA), osteoarthritis (OA) and mice with arthritis
demonstrated tyrosine hydroxylase-positive (TH+) cells in arthritic synovium and parallel …
demonstrated tyrosine hydroxylase-positive (TH+) cells in arthritic synovium and parallel …
Catecholaminergic-to-cholinergic transition of sympathetic nerve fibers is stimulated under healthy but not under inflammatory arthritic conditions
H Stangl, HR Springorum, D Muschter… - Brain, behavior, and …, 2015 - Elsevier
Objective: Density of sympathetic nerve fibers decreases in inflamed arthritic tissue tested by
immunoreactivity towards tyrosine-hydroxylase (TH, catecholaminergic key enzyme). Since …
immunoreactivity towards tyrosine-hydroxylase (TH, catecholaminergic key enzyme). Since …
The loss of sympathetic nerve fibers in the synovial tissue of patients with rheumatoid arthritis is accompanied by increased norepinephrine release from synovial …
LE Miller, H Jüsten, J Schcölmerich… - The FASEB …, 2000 - Wiley Online Library
Our objective was to investigate sym‐pathetic and sensory nerve fibers in synovial tissue in
rheumatoid arthritis (RA) and osteoarthritis (OA) in relation to histological inflammation and …
rheumatoid arthritis (RA) and osteoarthritis (OA) in relation to histological inflammation and …
An opposing time‐dependent immune‐modulating effect of the sympathetic nervous system conferred by altering the cytokine profile in the local lymph nodes and …
P Härle, D Möbius, DJJ Carr… - Arthritis & …, 2005 - Wiley Online Library
Objective The sympathetic nervous system (SNS) seems to play a proinflammatory role in
the early asymptomatic phase of arthritis, but its role in the late stages of chronic arthritis is …
the early asymptomatic phase of arthritis, but its role in the late stages of chronic arthritis is …
The anti-inflammatory effects of sympathectomy in murine antigen-induced arthritis are associated with a reduction of Th1 and Th17 responses
M Ebbinghaus, M Gajda, MK Boettger… - Annals of the …, 2012 - ard.bmj.com
Background Both facilitatory and inhibitory effects of the sympathetic nervous system (SNS)
on experimental arthritis have been reported. It is unknown whether such bidirectional …
on experimental arthritis have been reported. It is unknown whether such bidirectional …