The present study aimed to develop and characterize new formulations of dipyridamole
(DP), a pH-dependent poorly soluble drug, employing an acidic pH-modifier for improving …

This study was undertaken to develop new dipyridamole (DP) formulations with acidic
microenvironmental pH-modifiers for improving dissolution and absorption under …

The aim of this study was to develop new dipyridamole (DP) salts with pH-independent
solubility for improving oral bioavailability under hypochlorhydria. Salt screening was carried …

This study aimed to evaluate the usefulness of the dissolution/permeation system (D/P
system) as an in vitro tool for early screening of oral formulations of weakly basic drugs …

The objective of the present study is to develop sustained release of dipyridamole, a poorly
soluble weakly basic compound. The solubility of dipyridamole is the limit step of its …

The aim of this study was to develop a pH-independent release formulation of dipyridamole
(DP) by the combined use of pH-modifier technology and solid dispersion (SD) technology …

Dipyridamole (DPL) is a weakly basic BCS class II drug which precipitates upon entering
into intestine leading to pH dependant and variable absorption. Thus, research envisaged …

Introduction: Drug release and oral absorption of drugs with pH-dependent solubility are
influenced by the conditions in the gastrointestinal tract. In some cases, poor oral absorption …

The aim of this research was to design and evaluate a hydrophilic matrix system for
sustained release of glipizide, a weakly acidic poor soluble drug. A combination of inclusion …

Incorporation of weak acids as pH modifiers enhances the release of weakly basic drugs in
higher pH environments by reducing the microenvironmental pH (pHM). The objectives of …