Ischemic stroke is caused by a loss of blood flow and deficiency in glucose and oxygen to
the brain. The lack of sufficient glucose and oxygen results in varying degrees of tissue …

A brief, transient episode of cerebral ischemia causes selective loss of CA1 pyramidal cells
in the hippocampus. Interestingly, it takes 2–3 days for the neuronal damage of CA1 to …

The development of therapeutic interventions for cerebral ischemia requires a clear
understanding of cell death pathways. Historically, cell death following cerebral ischemia …

Stroke is one of leading causes of human disability and death. More than 17 million stroke
incidences occur in the world each year. In ischemic stroke (70–80% of all strokes) cerebral …

Ischemic stroke is the leading cause of long-term disability in adults. The primary reason for
the disability is the death of neurons in the cortex or subcortical nuclei. Following cerebral …

The concept of the ischemic penumbra was originally defined as the area around a necrotic
stroke core and seen as the tissue at imminent risk of further damage. Today, the penumbra …

Ischemic stroke is a very complex disorder with many intracellular and extracellular factors
such as excitatory amino acids, free radicals, calcium overload, apoptotic genes and …

Programmed cell death (PCD) is an ordered and tightly controlled set of changes in gene
expression and protein activity that results in neuronal cell death during brain development …

Background and Purpose—Traditionally, cell death after cerebral ischemia was considered
to be exclusively necrotic in nature, but research over the past decade has revealed that …

The mechanisms that trigger ischemic brain damage include a plethora of biochemical and
cellular events, such as glutamate-mediated excitotoxicity, generation of reactive oxygen …