Aberrant DNA methylation in gene promoters causes gene silencing and is a common event
in prostate cancer development and progression. While commonly identified methylated …

The prostate gland is the most common site of cancer and the second leading cause of
cancer death in American men. Recent emerging molecular biological technologies help us …

There is increasing evidence that DNA methylation is a critical source of gene regulation. In
addition, interindividual differences in DNA methylation status in cancer related genes are …

DNA methylation in gene promoters causes gene silencing and is a common event in
cancer development and progression. The ability of aberrant methylation events to serve as …

Prostate cancer (PCa) is the most prevailing cancer in the male population and the second-
leading cause of cancer-related death in the Western world. Although genomic alterations …

Background The prostate gland is the most common site of cancer and the second leading
cause of cancer mortality in American men. It is well known that epigenetic alterations such …

Background Promoter and 5′ end methylation regulation of tumour suppressor genes is a
common feature of many cancers. Such occurrences often lead to the silencing of these key …

Background Despite the significant global loss of DNA hydroxymethylation marks in prostate
cancer tissues, the locus-specific role of hydroxymethylation in prostate tumorigenesis is …

Promoter hypermethylation is associated with the loss of expression of tumor-suppressor
genes in cancer. Currently, several genome-wide technologies are available and have been …

Background: Prostate cancer (PCa) harbors a myriad of genomic and epigenetic defects.
Cytosine methylation of CpG-rich promoter DNA is an important mechanism of epigenetic …