[HTML][HTML] Epigenome-wide scans identify differentially methylated regions for age and age-related phenotypes in a healthy ageing population
Age-related changes in DNA methylation have been implicated in cellular senescence and
longevity, yet the causes and functional consequences of these variants remain unclear. To …
longevity, yet the causes and functional consequences of these variants remain unclear. To …
Cross-sectional and longitudinal changes in DNA methylation with age: an epigenome-wide analysis revealing over 60 novel age-associated CpG sites
I Florath, K Butterbach, H Müller… - Human molecular …, 2014 - academic.oup.com
Understanding the role of epigenetic modifications, eg DNA methylation, in the process of
aging requires the characterization of methylation patterns in large cohorts. We analysed> …
aging requires the characterization of methylation patterns in large cohorts. We analysed> …
Role of epigenetics in human aging and longevity: genome-wide DNA methylation profile in centenarians and centenarians' offspring
The role of epigenetics in the modulation of longevity has not been studied in humans. To
this aim,(1) we evaluated the DNA methylation from peripheral leukocytes of 21 female …
this aim,(1) we evaluated the DNA methylation from peripheral leukocytes of 21 female …
[HTML][HTML] Differential DNA methylation with age displays both common and dynamic features across human tissues that are influenced by CpG landscape
K Day, LL Waite, A Thalacker-Mercer, A West… - Genome biology, 2013 - Springer
Background DNA methylation is an epigenetic modification that changes with age in human
tissues, although the mechanisms and specificity of this process are still poorly understood …
tissues, although the mechanisms and specificity of this process are still poorly understood …
A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects
The central importance of epigenetics to the aging process is increasingly being recognized.
Here we perform a methylome-wide association study (MWAS) of aging in whole blood DNA …
Here we perform a methylome-wide association study (MWAS) of aging in whole blood DNA …
[HTML][HTML] An epigenome-wide association study of sex-specific chronological ageing
Background Advanced age is associated with cognitive and physical decline and is a major
risk factor for a multitude of disorders. There is also a gap in life expectancy between males …
risk factor for a multitude of disorders. There is also a gap in life expectancy between males …
[HTML][HTML] Ageing-associated changes in the human DNA methylome: genomic locations and effects on gene expression
S Marttila, L Kananen, S Häyrynen, J Jylhävä… - BMC genomics, 2015 - Springer
Background Changes in DNA methylation are among the mechanisms contributing to the
ageing process. We sought to identify ageing-associated DNA methylation changes at …
ageing process. We sought to identify ageing-associated DNA methylation changes at …
[HTML][HTML] Age-related accrual of methylomic variability is linked to fundamental ageing mechanisms
Background Epigenetic change is a hallmark of ageing but its link to ageing mechanisms in
humans remains poorly understood. While DNA methylation at many CpG sites closely …
humans remains poorly understood. While DNA methylation at many CpG sites closely …
[HTML][HTML] Age-related DNA methylation changes are tissue-specific with ELOVL2 promoter methylation as exception
Background The well-established association of chronological age with changes in DNA
methylation is primarily founded on the analysis of large sets of blood samples, while …
methylation is primarily founded on the analysis of large sets of blood samples, while …
Making sense of the ageing methylome
Over time, the human DNA methylation landscape accrues substantial damage, which has
been associated with a broad range of age-related diseases, including cardiovascular …
been associated with a broad range of age-related diseases, including cardiovascular …