We investigated whether single nucleotide polymorphisms within ultraconserved elements
(UCEs) are associated with susceptibility to overall colorectal cancer (CRC) and …

BACKGROUND: Ultraconserved elements (UCEs) are noncoding genomic sequences that
completely identical among human, mouse, and rat species and harbor critical biologic …

Background Common single-nucleotide polymorphisms (SNPs) in ten chromosomal loci
have been shown to predispose to colorectal cancer (CRC) in genome-wide association …

Objective An understanding of the etiologic heterogeneity of colorectal cancer (CRC) is
critical for improving precision prevention, including individualized screening …

Site‐specific variation in colorectal cancer (CRC) incidence, biology and prognosis are
poorly understood. We sought to determine whether common genetic variants influencing …

Background: Genomewide association studies have identified 10 low-penetrance loci that
confer modestly increased risk for colorectal cancer (CRC). Although they underlie a …

Background & Aims Known genetic factors explain only a small fraction of genetic variation
in colorectal cancer (CRC). We conducted a genome-wide association study to identify risk …

Colorectal cancer (CRC) is a common complex disease caused by the combination of
genetic variants and environmental factors. Genome-wide association studies (GWAS) have …

Recent genome-wide association studies have identified single-nucleotide polymorphisms
at 16 genetic loci associated with colorectal cancer risk: rs6691170 (1q41), rs10936599 …

Colorectal cancer (CRC) has an apparent hereditary component, as evidenced by the well-
characterized genetic syndromes and family history associated with the increased risk of this …