We summarize, in this review, the evidence that genomic balance influences gene
expression, quantitative traits, dosage compensation, aneuploid syndromes, population …

There is increasing evidence suggesting that stoichiometric imbalances in macromolecular
complexes and in signaling/transcriptional networks are a source of dosage-dependent …

Classical studies in genetics involving aneuploidy and ploidy comparisons and sex-
determination mechanisms indicated a balance phenomenon such that changes of …

The number of known human genes whose heterozygous null alleles lead to disease (ie
haploinsufficient genes) is increasing. A recent update shows that they encode preferentially …

The concept of genetic balance traces back to the early days of genetics. Additions or
subtractions of single chromosomes to the karyotype (aneuploidy) produced greater impacts …

Whole genome duplications (WGDs) followed by diploidization, which includes gene loss,
have been an important recurrent process in the evolution of higher eukaryotes. Gene …

THE gene dosage balance hypothesis (GDBH) pro- from the selective cost of their
overproduction. Thus, poses, in a narrow sense, that stoichiometric imbal-some genes …

Understanding buffering mechanisms for various perturbations is essential for
understanding robustness in cellular systems. Protein-level dosage compensation, which …

The gene balance hypothesis postulates that there is selection on gene copy number (gene
dosage) to preserve the stoichiometric balance among interacting proteins. This …

Dosage sensitivity is an important evolutionary force which impacts on gene dispensability
and duplicability. The newly available data on human copy-number variation (CNV) allow an …