Intronic RNAs mediate EZH2 regulation of epigenetic targets
S Guil, M Soler, A Portela, J Carrère… - Nature structural & …, 2012 - nature.com
Epigenetic deregulation at a number of genomic loci is one of the hallmarks of cancer. A role
for some RNA molecules in guiding repressive polycomb complex PRC2 to specific …
for some RNA molecules in guiding repressive polycomb complex PRC2 to specific …
[HTML][HTML] Regulatory interactions between RNA and polycomb repressive complex 2
C Cifuentes-Rojas, AJ Hernandez, K Sarma, JT Lee - Molecular cell, 2014 - cell.com
Summary Polycomb repressive complex 2 (PRC2) is a histone methyltransferase that is
localized to thousands of mammalian genes. Though important to human disease and as a …
localized to thousands of mammalian genes. Though important to human disease and as a …
[HTML][HTML] Conserved RNA-binding specificity of polycomb repressive complex 2 is achieved by dispersed amino acid patches in EZH2
Y Long, B Bolanos, L Gong, W Liu, KJ Goodrich… - Elife, 2017 - elifesciences.org
Polycomb repressive complex 2 (PRC2) is a key chromatin modifier responsible for
methylation of lysine 27 in histone H3. PRC2 has been shown to interact with thousands of …
methylation of lysine 27 in histone H3. PRC2 has been shown to interact with thousands of …
Phosphorylation of the PRC2 component Ezh2 is cell cycle-regulated and up-regulates its binding to ncRNA
Ezh2 functions as a histone H3 Lys 27 (H3K27) methyltransferase when comprising the
Polycomb-Repressive Complex 2 (PRC2). Trimethylation of H3K27 (H3K27me3) correlates …
Polycomb-Repressive Complex 2 (PRC2). Trimethylation of H3K27 (H3K27me3) correlates …
Molecular analysis of PRC2 recruitment to DNA in chromatin and its inhibition by RNA
X Wang, RD Paucek, AR Gooding, ZZ Brown… - Nature structural & …, 2017 - nature.com
Many studies have revealed pathways of epigenetic gene silencing by Polycomb repressive
complex 2 (PRC2) in vivo, but understanding the underlying molecular mechanisms …
complex 2 (PRC2) in vivo, but understanding the underlying molecular mechanisms …
EZH2 RIP-seq identifies tissue-specific long non-coding RNAs
Y Wang, Y Xie, L Li, Y He, D Zheng, P Yu… - Current gene …, 2018 - ingentaconnect.com
Background: Polycomb Repressive Complex 2 (PRC2) catalyzes histone methylation at H3
Lys27, and plays crucial roles during development and diseases in numerous systems. Its …
Lys27, and plays crucial roles during development and diseases in numerous systems. Its …
[HTML][HTML] Coordinated regulation of polycomb group complexes through microRNAs in cancer
Summary Polycomb Repressive Complexes (PRC1 and PRC2)-mediated epigenetic
regulation is critical for maintaining cellular homeostasis. Members of Polycomb Group …
regulation is critical for maintaining cellular homeostasis. Members of Polycomb Group …
Promiscuous RNA binding by Polycomb repressive complex 2
C Davidovich, L Zheng, KJ Goodrich… - Nature structural & …, 2013 - nature.com
Abstract Polycomb repressive complex 2 (PRC2) is a histone methyltransferase required for
epigenetic silencing during development and cancer. Long noncoding RNAs (lncRNAs) …
epigenetic silencing during development and cancer. Long noncoding RNAs (lncRNAs) …
The phosphatase interactor NIPP1 regulates the occupancy of the histone methyltransferase EZH2 at Polycomb targets
N Van Dessel, L Beke, J Görnemann… - Nucleic acids …, 2010 - academic.oup.com
Polycomb group (PcG) proteins are key regulators of stem-cell and cancer biology. They
mainly act as repressors of differentiation and tumor-suppressor genes. One key silencing …
mainly act as repressors of differentiation and tumor-suppressor genes. One key silencing …