Topiramate (TPM) treatment has been shown to reduce adiposity in humans and rodents.
The reduction in adiposity is related to decreased food intake and increased energy …

Topiramate (TPM) is a novel neurotherapeutic agent. Clinical studies reported that TPM
treatment reduced body weight and decreased fasting blood glucose levels in obese …

Materials and Methods: Fifty rats were assigned as normal, high fat diet (HFD), HFD+
sibutramine (7.5 mg/kg, po), HFD+ topiramate (25 mg/kg, po) and HFD+ topiramate (50 …

The effects of topiramate on food intake and body composition were investigated in rats fed
a high-fat diet and compared with rats that were pair fed or treated with d-fenfluramine …

Objective: This study examined the effects of topiramate (TPM), a novel neurotherapeutic
agent reported to reduce body weight in humans, on the components of energy balance in …

Objective Topiramate (TPM) has been reported to reduce body weight beyond a placebo in
the treatment of obese participants, but the effect of this agent on components of energy …

Topiramate (TPM) is a novel neurotherapeutic agent approved for the treatment of epilepsy
and for migraine prophylaxis. It has been observed that in obese-associated, type 2 diabetic …

Studies have shown that topiramate (TPM)-induced weight loss can be dependent on the
central nervous system (CNS). However, the direct action of TPM on adipose tissue has not …

Obesity has emerged as a widespread disease with epidemic proportions, necessitating
effective management to enhance the overall health outcomes of patients. Medical …

OBJECTIVE: The effects of topiramate (TPM) on components of energy balance were tested
in male and female rats that were (i) left intact,(ii) castrated or (iii) castrated with replacement …