Colorectal cancer (CRC) is the second most common newly diagnosed cancer and accounts
for the second highest number of cancer related deaths in Australia, the third worldwide and …

Colorectal cancer is a heterogeneous disease. There are three main pathways to colorectal
cancer: the chromosomal instability pathway, the CpG island methylator phenotype pathway …

Most of the colorectal cancer (CRC) cases are sporadic, only 25% of the patients have a
family history of the disease, and major genes causing syndromes predisposing to CRC only …

Colorectal cancer (CRC) is one of the major causes of mortality and morbidity, and is the
third most common cancer in men and the second most common cancer in women …

Colorectal cancer (CRC) is the second most common cancer in women and the third most
common in men globally. CRC arises from one or a combination of chromosomal instability …

Colorectal cancer (CRC) is a heterogeneous disease, developing through a multipathway
sequence of events guided by clonal selections. Pathways included in the development of …

Originally, colorectal cancer (CRC) tumorigenesis was understood as a multistep process
that involved accumulation of tumor suppressor genes and oncogenes mutations, such as …

Colorectal cancer (CRC) results from the progressive accumulation of multiple genetic and
epigenetic aberrations within cells. The progression from colorectal adenoma to carcinoma …

The past decade has seen the emergence of new pathways in the development of colorectal
cancer. There is now clear evidence that subsets of these tumours do not show …

The acquisition of genomic instability is a crucial feature in tumor development and there are
at least 3 distinct pathways in colorectal cancer pathogenesis: the chromosomal instability …