Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity
Rapamycin, an inhibitor of mechanistic target of rapamycin complex 1 (mTORC1), extends
the life spans of yeast, flies, and mice. Calorie restriction, which increases life span and …
the life spans of yeast, flies, and mice. Calorie restriction, which increases life span and …
Rapamycin has a biphasic effect on insulin sensitivity in C2C12 myotubes due to sequential disruption of mTORC1 and mTORC2
Rapamycin, an inhibitor of mTOR complex 1 (mTORC1), improves insulin sensitivity in acute
studies in vitro and in vivo by disrupting a negative feedback loop mediated by S6 kinase …
studies in vitro and in vivo by disrupting a negative feedback loop mediated by S6 kinase …
[HTML][HTML] Once again on rapamycin-induced insulin resistance and longevity: despite of or owing to
MV Blagosklonny - Aging (Albany NY), 2012 - ncbi.nlm.nih.gov
Calorie restriction (CR), which deactivates the nutrient-sensing mTOR pathway, slows down
aging and prevents age-related diseases such as type II diabetes. Compared with CR …
aging and prevents age-related diseases such as type II diabetes. Compared with CR …
Hypothalamic mTORC2 is essential for metabolic health and longevity
K Chellappa, JA Brinkman, S Mukherjee… - Aging …, 2019 - Wiley Online Library
The mechanistic target of rapamycin (mTOR) is an evolutionarily conserved protein kinase
that regulates growth and metabolism. mTOR is found in two protein complexes, mTORC1 …
that regulates growth and metabolism. mTOR is found in two protein complexes, mTORC1 …
mTORC1 phosphorylation sites encode their sensitivity to starvation and rapamycin
Introduction The mechanistic target of rapamycin (mTOR) complex 1 (mTORC1) protein
kinase promotes cell growth by controlling major anabolic and catabolic processes in …
kinase promotes cell growth by controlling major anabolic and catabolic processes in …
mTORC1-mediated cell proliferation, but not cell growth, controlled by the 4E-BPs
RJO Dowling, I Topisirovic, T Alain, M Bidinosti… - Science, 2010 - science.org
The mammalian target of rapamycin complex 1 (mTORC1) integrates mitogen and nutrient
signals to control cell proliferation and cell size. Hence, mTORC1 is implicated in a large …
signals to control cell proliferation and cell size. Hence, mTORC1 is implicated in a large …
[HTML][HTML] Calorie-restriction-induced insulin sensitivity is mediated by adipose mTORC2 and not required for lifespan extension
Calorie restriction (CR) extends the healthspan and lifespan of diverse species. In
mammals, a broadly conserved metabolic effect of CR is improved insulin sensitivity, which …
mammals, a broadly conserved metabolic effect of CR is improved insulin sensitivity, which …
Duration of rapamycin treatment has differential effects on metabolism in mice
Y Fang, R Westbrook, C Hill, RK Boparai, O Arum… - Cell metabolism, 2013 - cell.com
The evolutionarily conserved target of rapamycin (TOR) signaling controls growth,
metabolism, and aging. In the first robust demonstration of pharmacologically-induced life …
metabolism, and aging. In the first robust demonstration of pharmacologically-induced life …
Rapamycin induces glucose intolerance in mice by reducing islet mass, insulin content, and insulin sensitivity
Rapamycin, a specific inhibitor for mTOR complex 1, is an FDA-approved
immunosuppressant for organ transplant. Recent developments have raised the prospect of …
immunosuppressant for organ transplant. Recent developments have raised the prospect of …
A novel rapamycin analog is highly selective for mTORC1 in vivo
KH Schreiber, SI Arriola Apelo, D Yu… - Nature …, 2019 - nature.com
Rapamycin, an inhibitor of mechanistic Target Of Rapamycin Complex 1 (mTORC1),
extends lifespan and shows strong potential for the treatment of age-related diseases …
extends lifespan and shows strong potential for the treatment of age-related diseases …