The inhibitor of nuclear factor‐κB (IκB) kinase (IKK) complex is the master regulator of the NF‐
κB signaling pathway. The activation of the IKK complex is a tightly regulated, highly …

The IκB kinase (IKK) complex is the signal integration hub for NF‐κB activation. Composed
of two serine‐threonine kinases (IKK α and IKK β) and the regulatory subunit NEMO (also …

Abstract The Nuclear Factor-kappa B (NF-κB) family of transcription factors regulates the
expression of a wide range of genes critical for immune and inflammatory responses, cell …

Background Activation of the transcription factor NF-κB by cytokines is rapid, mediated
through the activation of the IKK complex with subsequent phosphorylation and degradation …

NF-κB (nuclear factor-κB) is a collective name for inducible dimeric transcription factors
composed of members of the Rel family of DNA-binding proteins that recognize a common …

Abstract IκB kinase (IKK) complex, the master kinase for NF-κB activation, contains two
kinase subunits, IKKα and IKKβ. In addition to mediating NF-κB signaling by phosphorylating …

Nuclear factor (NF)-κB and inhibitor of NF-κB kinase (IKK) proteins regulate many
physiological processes, including the innate-and adaptive-immune responses, cell death …

Rel/NF-κB transcription factors are primarily regulated by association with inhibitor IκB
proteins. Thus, in most cells NF-κB exists in the cytoplasm in an inactive complex bound to …

In addition to regulating immune responses, the NF-κB family of transcription factors also
promotes cellular proliferation and survival. NF-κB and its activating kinase, IKK, have …

Activation of the transcription factor NF-κB is controlled by the sequential phosphorylation,
ubiquitination, and degradation of its inhibitory subunit, IκB. We recently purified a large …