The soluble ectodomain of fibroblast growth factor receptor-IIIc (sFGFR2c) is able to bind to
fibroblast growth factor (FGF) ligands and block the activation of the FGF-signaling pathway …

We have developed a strong inhibitor (S252W mutant soluble ectodomain of fibroblast
growth factor recptor-2 IIIc, msFGFR2) that binds FGFs strongly and blocks the activation of …

Pulmonary fibrosis (PF) is chronic and irreversible damage to the lung characterized by
fibroblast activation and matrix deposition. Although recently approved novel anti‐fibrotic …

Idiopathic pulmonary fibrosis (IPF) is characterized by progressive fibroblast and
myofibroblast proliferation, and extensive deposition of extracellular matrix (ECM). Fibroblast …

Background Recent clinical studies show that tyrosine kinase inhibitors slow the rate of lung
function decline and decrease the number of acute exacerbations in patients with Idiopathic …

Transforming growth factor (TGF)-β1 has long been regarded as a central mediator of tissue
fibrosis. Follistatin-like 1 (Fstl1) is a crucial profibrotic glycoprotein that is upregulated in …

Fibroblast growth factor (FGF) signaling has been shown to regulate lung epithelial
development but its influence on mesenchymal differentiation has been poorly investigated …

Pulmonary fibrosis, a severe condition that can progress to respiratory failure and death, is
characterized by aberrant activation/proliferation of fibroblasts and excessive extracellular …

Idiopathic pulmonary fibrosis (IPF) is characterized by an accumulation of extracellular
matrix proteins and fibroblasts in the distal airways. Key developmental lung signaling …

Transforming growth factor-β1 (TGF-β1) is a multifunctional cytokine that induces
mesenchymal cell proliferationin vivowhile inhibiting growth of most cells directly via serine …