NF‐κB and the link between inflammation and cancer
The nuclear factor‐κB (NF‐κB) transcription factor family has been considered the central
mediator of the inflammatory process and a key participant in innate and adaptive immune …
mediator of the inflammatory process and a key participant in innate and adaptive immune …
NF-κB as a critical link between inflammation and cancer
M Karin - Cold Spring Harbor perspectives in biology, 2009 - cshperspectives.cshlp.org
NF-κB transcription factors have been suspected to be involved in cancer development
since their discovery because of their kinship with the v-Rel oncogene product. Subsequent …
since their discovery because of their kinship with the v-Rel oncogene product. Subsequent …
Inflammation-associated cancer: NF-κB is the lynchpin
It has long been suspected that NF-κB signaling has a pivotal role in chronic inflammation-
associated malignancies, although genetic evidence for this hypothesis has been lacking …
associated malignancies, although genetic evidence for this hypothesis has been lacking …
NF-κB, inflammation, immunity and cancer: coming of age
K Taniguchi, M Karin - Nature Reviews Immunology, 2018 - nature.com
Fourteen years have passed since nuclear factor-κB (NF-κB) was first shown to serve as a
molecular lynchpin that links persistent infections and chronic inflammation to increased …
molecular lynchpin that links persistent infections and chronic inflammation to increased …
[HTML][HTML] NF-κB and cancer: a paradigm of Yin-Yang
G Xiao, J Fu - American journal of cancer research, 2011 - ncbi.nlm.nih.gov
Recent studies have clearly linked nuclear factor-kappaB (NF-κB), a transcription factor that
plays a central role in regulating immune and inflammatory responses, to tumor …
plays a central role in regulating immune and inflammatory responses, to tumor …
NF-κB, an active player in human cancers
NF-κB comprises a family of five transcription factors that form distinct protein complexes,
which bind to consensus DNA sequences at promoter regions of responsive genes …
which bind to consensus DNA sequences at promoter regions of responsive genes …
Inflammation meets cancer, with NF-κB as the matchmaker
Y Ben-Neriah, M Karin - Nature immunology, 2011 - nature.com
Inflammation is a fundamental protective response that sometimes goes awry and becomes
a major cofactor in the pathogenesis of many chronic human diseases, including cancer …
a major cofactor in the pathogenesis of many chronic human diseases, including cancer …
[HTML][HTML] NF-kappaB: two sides of the same coin
BRB Pires, RCMC Silva, GM Ferreira, E Abdelhay - Genes, 2018 - mdpi.com
Nuclear Factor-kappa B (NF-κB) is a transcription factor family that regulates a large number
of genes that are involved in important physiological processes, including survival …
of genes that are involved in important physiological processes, including survival …
NF-κB in cancer: from innocent bystander to major culprit
M Karin, Y Cao, FR Greten, ZW Li - Nature reviews cancer, 2002 - nature.com
Nuclear factor of κB (NF-κB) is a sequence-specific transcription factor that is known to be
involved in the inflammatory and innate immune responses. Although the importance of NF …
involved in the inflammatory and innate immune responses. Although the importance of NF …
NF‐κB and cancer: Mechanisms and targets
M Karin - … Carcinogenesis: Published in cooperation with the …, 2006 - Wiley Online Library
In addition to being a central coordinator of immune responses, NF‐κB signaling also plays
a critical role in cancer development and progression and it may determine the response to …
a critical role in cancer development and progression and it may determine the response to …