Osteoporosis is a common polygenic disease and global healthcare priority but its genetic
basis remains largely unknown. We report a high-throughput multi-parameter phenotype …

Purpose of review The international mouse phenotyping consortium (IMPC) is producing
defined gene knockout mouse lines. Here, a phenotyping program is presented that is …

The genetic determinants of osteoporosis remain poorly understood, and there is a large
unmet need for new treatments in our ageing society. Thus, new approaches for gene …

Very low bone mineral density (BMD) is now considered as diagnostic of osteoporosis.
Moreover, many women who are osteopenic eventually develop osteoporotic fractures …

Osteoporosis is a skeletal disorder characterized by compromised bone strength that
predisposes a person to an increased risk of fracture. Osteoporosis is a complex trait that …

Genetics of Bone Biology and Skeletal Disease, Second Edition, is aimed at students of
bone biology and genetics and includes general introductory chapters on bone biology and …

Osteoporosis is a common disease with a strong genetic component characterized by
reduced bone mass and increased risk of fragility fractures. Twin and family studies have …

The genetic landscape of diseases associated with changes in bone mineral density (BMD),
such as osteoporosis, is only partially understood. Here, we explored data from 3,823 …

The advancement of human genomics has revolutionized our understanding of the genetic
architecture of many skeletal diseases, including osteoporosis. However, interpreting results …

Osteoporosis is a complex human disease that results in increased susceptibility to fragility
fractures. It can be phenotypically characterized using several traits, including bone mineral …