Background: Dopamine has been proven to be toxic for melanocytes. In vitiligo patients the
level of dopamine is increased and the functioning of several enzymes participating in the …

Catecholamines (epinephrine, norepinephrine and dopamine) are considered toxic to the
melanocytes and may play an important role in the development of depigmented patches on …

BACKGROUND: Main pathway in human melanocytes through which signal from the
melanocortin system reaches the melanogenesis enzymes is cAMP/PKA pathway and it is …

BACKGROUND: The melanocortin system in the skin coordinates pigmentation and immune
response and could be implicated in the pathogenesis of vitiligo. OBJECTIVES: We aimed to …

Our study aimed to identify the key genes and upstream regulators in vitiligo. To screen the
pathogenic genes of vitiligo, an integrated analysis was performed by using the microarray …

Vitiligo is a disorder characterised by depigmented patches in skin. In the involved vitiligo
skin melanocytes are partially or completely lost, and no melanin is synthesized. The cause …

Proopiomelanocortin (POMC) and melanocortin 1 receptor (MC1R) are regulators of
melanogenesis and pigmentation. Our objective was to estimate their levels, searching for a …

Abstract Background Chemicals like Monobenzyl Ether of Hydroquinone (MBEH) and 4-
Tertiary Butyl Phenol (4-TBP) have been widely recognized to induce clinical lesions that …

Vitiligo is a disorder causing skin depigmentation, in which several factors have been
proposed for its pathogenesis: Environmental, genetic and biological aspects of …

Vitiligo is one of the most troubling diseases to both patient and physician. Monoamines are
chemical compounds derived from the hydroxyderivative of amino acids. They have been …