Saving lives by training innate immunity with bacille Calmette-Guerin vaccine

P Aaby, CS Benn - Proceedings of the National Academy of …, 2012 - National Acad Sciences
For many years, public health practitioners have been puzzled by the fact that vaccines
developed to fight specific diseases also have nonspecific effects that alter the host …

Bacillus Calmette-Guerin vaccination and infant mortality

A Roth, ML Garly, H Jensen, J Nielsen… - Expert review of …, 2006 - Taylor & Francis
When the bacillus Calmette-Guérin (BCG) vaccine was introduced in the 1920s, it was
suggested that BCG occasionally had nonspecific beneficial effects on mortality beyond the …

[HTML][HTML] 100 years of the Bacillus Calmette-Guérin vaccine

PJG Bettencourt, SA Joosten, CSL Arlehamn, MA Behr… - Vaccine, 2021 - ncbi.nlm.nih.gov
On July 18, 2021, the world celebrated the 100th anniversary of the first administration of
Bacillus Calmette-Guérin (BCG), the only licensed vaccine against tuberculosis (TB) to date …

[HTML][HTML] Bacille Calmette-Guérin vaccine strain modulates the ontogeny of both mycobacterial-specific and heterologous T cell immunity to vaccination in infants

A Kiravu, S Osawe, AU Happel, T Nundalall… - Frontiers in …, 2019 - frontiersin.org
Differences in Bacille Calmette-Guérin (BCG) immunogenicity and efficacy have been
reported, but various strains of BCG are administered worldwide. Since BCG immunization …

[HTML][HTML] Bacille Calmette-Guérin (BCG) vaccination at birth and antibody responses to childhood vaccines. A randomised clinical trial

TN Nissen, NM Birk, G Smits, DL Jeppesen… - Vaccine, 2017 - Elsevier
Introduction BCG vaccination has been associated with beneficial non-specific effects on
child health. Some immunological studies have reported heterologous effects of vaccines on …

[HTML][HTML] Bacillus Calmette-Guerin (BCG): the adroit vaccine

OA Adesanya, CI Uche-Orji, YA Adedeji… - AIMS …, 2021 - ncbi.nlm.nih.gov
Background The Bacillus Calmette-Guerin (BCG) vaccine has been in use for 99 years, and
is regarded as one of the oldest human vaccines known today. It is recommended primarily …

Making wider use of the world's most widely used vaccine: Bacille Calmette–Guérin revaccination reconsidered

C Dye - Journal of the Royal Society Interface, 2013 - royalsocietypublishing.org
Approximately 100 million newborn children receive Bacille Calmette–Guérin (BCG)
annually, because vaccination is consistently protective against childhood tuberculous …

[HTML][HTML] BCG as a case study for precision vaccine development: lessons from vaccine heterogeneity, trained immunity, and immune ontogeny

A Angelidou, J Diray-Arce, MG Conti… - Frontiers in …, 2020 - frontiersin.org
Vaccines have been traditionally developed with the presumption that they exert identical
immunogenicity regardless of target population and that they provide protection solely …

The immunological effect of revaccination with Bacille Calmette-Guérin vaccine at 19 months of age

A Andersen, A Roth, KJ Jensen, C Erikstrup, IM Lisse… - Vaccine, 2013 - Elsevier
Abstract Background Bacille Calmette-Guérin (BCG) vaccination has important non-specific
immune effects. In a randomized trial in Guinea-Bissau, BCG revaccination was associated …

Editorial Commentary: Different Strains of Bacillus Calmette–Guérin Vaccine Have Very Different Effects on Tuberculosis and on Unrelated Infections

F Shann - Clinical Infectious Diseases, 2015 - academic.oup.com
Bacillus Calmette–Guérin (BCG) vaccine provides good protection against disseminated
mycobacterial diseases such as miliary tuberculosis, tuberculous meningitis, and leprosy [1 …