Abstract Interleukin-7 (IL-7) mediates T-cell homeostasis through its effects on T-cell
development, survival and function. In human T-cell lymphotropic virus type 1 (HTLV-1) …

HIV Tat protein downregulates surface expression of the interleukin-7 receptor alpha-chain
(CD127) on CD8 T cells resulting in impaired T cell proliferation and cytolytic capacity. Once …

0001. This application claims benefit of priority to provi sional application Ser. No.
60/944.288 filed on Jun. 15, 2007 and further claims priority to and is a continuation-in-part …

Currently approved adjuvants induce protective antibody responses but are more limited for
generating cellular immunity. Here we assessed the effect of combining two adjuvants with …

Pancreatic adenocarcinoma (PAC) is a very aggressive cancer with a poor prognosis. To
date, the causes and pathogenetic mechanisms involved in the development of this …

Due to a unique pattern of CD8 T-cell response induced by cytomegaloviruses (CMVs), live
attenuated CMVs are attractive candidates for vaccine vectors for a number of clinically …

Human cytomegalovirus (CMV) remains an important complication in allogeneic
hematopoietic stem cell transplantation (HSCT). CMV-reactivation may lead to CMV-disease …

Typ I Interferon stellt einen essentiellen Teil der angeborenen Immunantwort dar und besitzt
antivirale und immunmodulatorische Eigenschaften. Diese Funktionen werden durch die …

Natural killer (NK) cells are a critical component of the immune response against viral
infections. NK cell depletion prior to murine cytomegalovirus (MCMV) infections results in …

Humanized mice have emerged as a promising model to study human immunity in vivo.
Although they are susceptible to many pathogens exhibiting an almost exclusive human …