The CD4-centered universe of human T cell subsets
Humans are continuously exposed to a high number of diverse pathogens that induce
different types of immune responses. Primary pathogen-specific immune responses …
different types of immune responses. Primary pathogen-specific immune responses …
Longitudinal Changes in CD4+ T-Cell Memory Responses Induced by BCG Vaccination of Newborns
AP Soares, CKC Kwong Chung… - The Journal of …, 2013 - academic.oup.com
Background. Improved vaccination strategies against tuberculosis are needed, such as
approaches to boost immunity induced by the current vaccine, BCG. Design of these …
approaches to boost immunity induced by the current vaccine, BCG. Design of these …
Comparative analysis of the magnitude, quality, phenotype, and protective capacity of simian immunodeficiency virus gag-specific CD8+ T cells following human …
KM Quinn, A Da Costa, A Yamamoto… - The Journal of …, 2013 - journals.aai.org
Recombinant adenoviral vectors (rAds) are the most potent recombinant vaccines for
eliciting CD8+ T cell–mediated immunity in humans; however, prior exposure from natural …
eliciting CD8+ T cell–mediated immunity in humans; however, prior exposure from natural …
Potential roles for CD8+ T cells in rheumatoid arthritis
CD8+ T cells have long been suggested to play a role in rheumatoid arthritis (RA). The
current paradigm on the pathogenesis and maintenance of the disease would endorse …
current paradigm on the pathogenesis and maintenance of the disease would endorse …
Interleukin-7: Fuel for the autoimmune attack
H Dooms - Journal of autoimmunity, 2013 - Elsevier
Abstract Interleukin-7 (IL-7) is a critical survival factor for lymphocytes and recent studies
suggest targeting the IL-7/IL-7Rα pathway holds promise for the treatment of autoimmune …
suggest targeting the IL-7/IL-7Rα pathway holds promise for the treatment of autoimmune …
T-cell immunophenotyping distinguishes active from latent tuberculosis
KM Pollock, HS Whitworth… - The Journal of …, 2013 - academic.oup.com
Background. Changes in the phenotype and function of Mycobacterium tuberculosis (M.
tuberculosis)-specific CD4+ and CD8+ T-cell subsets in response to stage of infection may …
tuberculosis)-specific CD4+ and CD8+ T-cell subsets in response to stage of infection may …
GATA-3 controls the maintenance and proliferation of T cells downstream of TCR and cytokine signaling
Y Wang, I Misumi, AD Gu, TA Curtis, L Su… - Nature …, 2013 - nature.com
GATA-3 controls T helper type 2 (TH2) differentiation. However, whether GATA-3 regulates
the function of mature T cells beyond TH2 determination remains poorly understood. We …
the function of mature T cells beyond TH2 determination remains poorly understood. We …
[HTML][HTML] Preexisting high frequencies of memory CD8+ T cells favor rapid memory differentiation and preservation of proliferative potential upon boosting
Memory CD8+ T cell quantity and quality determine protective efficacy against reinfection.
Heterologous prime boost vaccination minimizes contraction of anamnestic effectors and …
Heterologous prime boost vaccination minimizes contraction of anamnestic effectors and …
MicroRNA-17∼ 92 regulates effector and memory CD8 T-cell fates by modulating proliferation in response to infections
AA Khan, LA Penny, Y Yuzefpolskiy… - Blood, The Journal …, 2013 - ashpublications.org
The precise microRNAs and their target cellular processes involved in generation of durable
T-cell immunity remain undefined. Here we show a dynamic regulation of microRNAs as …
T-cell immunity remain undefined. Here we show a dynamic regulation of microRNAs as …
MicroRNA-directed program of cytotoxic CD8+ T-cell differentiation
S Trifari, ME Pipkin, HS Bandukwala… - Proceedings of the …, 2013 - National Acad Sciences
Acquisition of effector properties is a key step in the generation of cytotoxic T lymphocytes
(CTLs). Here we show that inflammatory signals regulate Dicer expression in CTLs, and that …
(CTLs). Here we show that inflammatory signals regulate Dicer expression in CTLs, and that …