Ag-specific memory T cell responses elicited by infections or vaccinations are inextricably
linked to long-lasting protective immunity. Studies of protective immunity among residents of …

Friend virus infection of mice induces the expansion and activation of regulatory T cells
(Tregs) that dampen acute immune responses and promote the establishment and …

Liver sinusoidal endothelial cell lectin (LSECtin) was recently reported to suppress
intrahepatic T cell immunity and to limit immune-mediated liver injury. However, its role in …

BACKGROUND: Wiskott-Aldrich syndrome (WAS) is a rare X-linked primary
immunodeficiency caused by absence of Wiskott-Aldrich syndrome protein (WASP) …

Due to a unique pattern of CD8 T-cell response induced by cytomegaloviruses (CMVs), live
attenuated CMVs are attractive candidates for vaccine vectors for a number of clinically …

The human polyomavirus BK virus (BKV) establishes a latent and asymptomatic infection in
the majority of the population. In immunocompromised individuals, the virus frequently (re) …

CD8+ T cell immune responses provide immediate protection against primary infection and
durable memory capable of rapidly fighting off re-infection. Immediate protection and lasting …

TNF is an important inflammatory mediator and a target for intervention. TNF is produced by
many cell types and is involved in innate inflammation as well as adaptive immune …

Adenosine monophosphate‐activated protein kinase (AMPK) is a serine/threonine kinase
and is crucial for cellular energy homeostasis. The exact role of AMPK during memory CD …

In addition to archetypal cognitive defects, D own syndrome (DS) is characterized by altered
lymphocyte development and function, including premature thymic involution and increased …