Children with D own syndrome (DS) have a greater risk for developing both acute
lymphoblastic leukaemia (ALL) and significant adverse effects of chemotherapy. We …

The somatic genomic alterations in pediatric cancers to some extent overlap with those seen
in adult cancers, but the exact distribution throughout the genome and the types and …

Chromosomal translocations involving the immunoglobulin heavy chain locus (IGH@) are
recurrent but rare in B-cell precursor acute lymphoblastic leukemia (BCP-ALL), and various …

Acute leukemia represents 31% of all cancers diagnosed in children and 80% of it is of
Lymphoblastic type. Multiple genetic lesions in the hematopoietic progenitor cells prior to or …

Considerable attention has focused on the gain-of-function mutations in the Janus kinase-2
(JAK2) tyrosine kinase that are detectable in most patients with a myeloproliferative …

Acute leukemias are characterized by recurring chromosomal and genetic abnormalities that
disrupt normal development and drive aberrant cell proliferation and survival. Identification …

The thirteenth international childhood acute lymphoblastic leukemia workshop report: La Jolla,
CA, USA, December 7-9, 2011 The thirteenth international childhood acute lymphoblastic …

The article focuses on a study which aims to determine the impact of cytokine receptor like
factor-2 (CRLF2) gene on patients with B-cell precursor acute lymphoblastic leukaemia …

B‐precursor acute lymphoblastic leukemia (B‐ALL) lymphoblast (blast) internalization of anti‐
cytokine receptor‐like factor 2 (CRLF2) antibody‐armored biodegradable nanoparticles …

Acute lymphoblastic leukemia (ALL) in adolescents and young adults (AYA) represents a
unique and challenging disease entity. Despite the recent improvement of survival in this …