RhoB, one of the upstream signaling proteins of the phosphatidylinositol-3-kinase (PI3K)/Akt
pathway, is frequently mutated in human cancer. Based on a piperazine alkyl derivative that …

Pİ3K-AKT-mTOR yolağı farklı kanser türlerinde hücre büyümesi, tümör oluşumu ve tümör
invazyonuna sebep olan bir yolaktır. PTEN bu yolakta esas olarak tümör invazyonunu ve …

The failure of farnesyltransferase inhibitors to show antitumor activity against KRAS-mutant
malignancies diminished enthusiasm for efforts to develop anti-Ras inhibitors for cancer …

Oncogenic K-Ras proteins, such as K-RasG12D, accumulate in the active, guanosine
triphosphate (GTP)–bound conformation and stimulate signaling through effector kinases …

Oncogenes drive cancer by hijacking normal cellular functions involved in proliferation and
survival. Suppression of the driving oncogene is highly effective for promoting tumor …

Introduction: Over the past decades, considerable advances in understanding of cell biology
at genetic, epigenetic and proteomic levels led to development of new strategies for better …

Role of Intersectin in Cell Signaling Katy Ann Wong, Ph. D. Department of Pharmacology
University of Illinois at Chicago Chicago, Illinois (2012) Dissertation Chairperson:(John P …

Since their discovery in 1986, Ral (Ras-like) GTPases have emerged as critical regulators of
diverse cellular functions. Like Ras, the Ral proteins cycle between an inactive GDP-bound …

The tumor microenvironment results in several cellular stresses including hypoxia and
nutrient deprivation. In order to adapt to such conditions, the cell can utilize several stress …