We have recently demonstrated strong nuclear deformation of SaOs-2 osteosarcoma cells
on poly-l-lactic acid (PLLA) micropillar substrates. In the present study, we first demonstrated …

Engineered topographical manipulation, a paralleling approach with conventional
biochemical cues, has recently attracted the growing interests in utilizations to control stem …

Tissue engineering aims to repair, restore, and regenerate lost or damaged tissues by using
biomaterials, cells, mechanical forces and factors (chemical and biological) alone or in …

The purpose of the study is to investigate the effects of electrospun fiber diameter and
orientation on differentiation and ECM organization of bone marrow stromal cells (BMSCs) …

Controlling the cellular microenvironment can be used to direct the cellular organization,
thereby improving the function of synthetic tissues in biosensing, biorobotics, and …

Engineered tissues require enhanced organization of cells and the extracellular matrix
(ECM) for proper function. To promote cell organization, substrates with controlled micro-and …

Combining clay minerals containing silica with polymers can improve the performance of
polymers in biomedical applications by the synergistic combination of physico-chemical and …

Understanding and accelerating the mechanisms of endothelial wound healing is of
fundamental interest for biotechnology and of significant medical utility in repairing …

Human (h) pluripotent stem cells (PSC) such as embryonic stem cells (ESC) can be directed
into cardiomyocytes (CMs), representing a potential unlimited cell source for disease …

Surface wrinkling of materials offers a simple yet elegant approach to fabricating cell culture
substrates with highly ordered topographies for investigating cell mechanobiology. In this …