During the 1980s the structure–function relationship of nonsteroidal estrogens and
antiestrogens using an a prolactin gene target in primary cultures of rat pituitary cells created …

Estrogens and anti estrogens are understood to exert their hormonal action after binding to
the estrogen receptor (ER), a member of the nuclear receptor superfamily. Until recently, the …

Estrogen receptor modulators are recognised as playing a central role in the regulation of
many endocrine functions. In recent years, the discovery of many new members of this class …

Estrogens exert profound effects on the physiology of diverse target cells and these effects
appear to be mediated by two estrogen receptor (ER) subtypes, ERα and ERβ. We have …

Our appreciation of the physiological functions of estrogens and the mechanisms through
which estrogens bring about these functions has changed during the past decade. Just as …

Because the ligand bound to the ligand-binding domain (LBD) of nuclear hormone receptors
is completely enveloped by protein, it is thought that the process of ligand binding or …

Here we review the results that have emerged from our structural studies on the oestrogen
receptor ligand-binding domain (ER-LBD). The effects of agonists and antagonists on the …

The 2.8-Å crystal structure of the complex formed by estradiol and the human estrogen
receptor-α ligand binding domain (hERαLBD) is described and compared with the recently …

We have previously examined, by alanine scanning mutagenesis, amino acids 515-535 of
the estrogen receptor (ER) ligand binding domain to determine which of these residues are …

Estrogens exert a wide variety of effects on growth, development, and differentiation,
including important regulatory functions within the reproductive systems of both females and …