Previous studies of the effect of ART on gene expression in HIV-infected individuals have
identified small numbers of modulated genes. Since these studies were underpowered or …

Background Although the host gene expression in the context of HIV has been explored by
several studies, it remains unclear how HIV is able to manipulate and subvert host gene …

Background: Most HIV-infected cells during antiretroviral therapy (ART) persist in lymphoid
tissues. Studies disagree on whether suboptimal tissue ART concentrations contribute to …

Background Many genome-wide association studies have been performed on progression
towards the acquired immune deficiency syndrome (AIDS) and they mainly identified …

Objective: HIV pathogenesis is characterized by destructive imbalances between virus-
mediated immune damage, antiviral immune responses, and immune activation. We …

In most people living with HIV (PLWH) on effective antiretroviral therapy (ART), cell-
associated viral transcripts are readily detectable in CD4+ T cells despite the absence of …

The functional impairment and numerical decline of CD8+ T cells during HIV infection has a
profound effect on disease progression, but only limited microarray studies have used CD8+ …

Plasma HIV RNA shows no evidence for evolution during ART, suggesting that HIV
persistence is not driven by low-level, ongoing replication. The emergence of identical viral …

Background HIV-infected cell lines are widely used to study latent HIV infection, which is
considered the main barrier to HIV cure. We hypothesized that these cell lines differ from …

Background: HIV-1 transcription during suppressive antiretroviral therapy (ART) is not well
understood. This is problematic as latency-reactivating agent-based HIV-1 eradication trials …