Interazione in cis di notch3 e jagged1: identificazione di un nuovo meccanismo molecolare coinvolto nella progressione della leucemia linfoblastica acuta a cellule T
M Pelullo - 2013 - iris.uniroma1.it
La via di segnalazione dei recettori di membrana appartenenti alla famiglia Notch è
estremamente conservata dagli Invertebrati ai Vertebrati e regola numerosi eventi quali …
estremamente conservata dagli Invertebrati ai Vertebrati e regola numerosi eventi quali …
Identification of novel Notch target genes in T cell leukaemia
N Chadwick, L Zeef, V Portillo, C Fennessy… - Molecular cancer, 2009 - Springer
Abstract Background Dysregulated Notch signalling is believed to play an important role in
the development and maintenance of T cell leukaemia. At a cellular level, Notch signalling …
the development and maintenance of T cell leukaemia. At a cellular level, Notch signalling …
A wide role for NOTCH1 signaling in acute leukemia
R Chiaramonte, A Basile, E Tassi, E Calzavara… - Cancer letters, 2005 - Elsevier
NOTCH1 is involved in the pathogenesis of T-acute lymphoblastic leukemia (T-ALL) carrying
the very rare translocation t (7; 9)(q34; q34. 3). We analyzed the expression of genes …
the very rare translocation t (7; 9)(q34; q34. 3). We analyzed the expression of genes …
Detection the Expression of Notch and Its Related Molecules in Bone Marrow Cells of Acute Leukemia Patients by Quantitative Real-Time RT-PCR.
Y Zhou, Z Chen, K Kenichi, S Kazuo, W Wang, J Cen - 2005 - ashpublications.org
The notch family of transmembrane receptors play crucial roles in cell fate determination
through interaction with the Delta/Serrate/Lag-2 family of ligands. The transcription of the …
through interaction with the Delta/Serrate/Lag-2 family of ligands. The transcription of the …
[HTML][HTML] Notch3/Jagged1 circuitry reinforces notch signaling and sustains T-ALL
M Pelullo, R Quaranta, C Talora, S Checquolo, S Cialfi… - Neoplasia, 2014 - Elsevier
Deregulated Notch signaling has been extensively linked to T-cell acute lymphoblastic
leukemia (T-ALL). Here, we show a direct relationship between Notch3 receptor and …
leukemia (T-ALL). Here, we show a direct relationship between Notch3 receptor and …
Alternative promoter usage at the Notch1 locus supports ligand-independent signaling in T cell development and leukemogenesis
P Gómez-del Arco, M Kashiwagi, AF Jackson, T Naito… - Immunity, 2010 - cell.com
Loss of the transcription factor Ikaros is correlated with Notch receptor activation in T cell
acute lymphoblastic leukemia (T-ALL). However, the mechanism remains unknown. We …
acute lymphoblastic leukemia (T-ALL). However, the mechanism remains unknown. We …
[PDF][PDF] Oncogenic activation of the Notch1 gene by deletion of its promoter in
T Ikaros-deficient - development, 2010 - academia.edu
The Notch pathway is frequently activated in T-cell acute lymphoblastic leukemias (T-ALLs).
Of the Notch receptors, Notch1 is a recurrent target of gain-offunction mutations and Notch3 …
Of the Notch receptors, Notch1 is a recurrent target of gain-offunction mutations and Notch3 …
Dialing resistance up a Notch
D Sampath, V Gandhi - Leukemia & lymphoma, 2009 - Taylor & Francis
Notch proteins function in hematopoietic cells as both cell surface receptors and direct
regulators of gene transcription. The Notch ligands (Jagged 1 and 2, Delta-like 1, 2 and 4) …
regulators of gene transcription. The Notch ligands (Jagged 1 and 2, Delta-like 1, 2 and 4) …
Transcriptional Regulatory Networks Downstream of NOTCH1 in T-Cell Acute Lymphoblastic Leukemia.
The NOTCH1 signaling pathway plays a critical role in the regulation of hematopoietic stem
cell homeostasis and is required for lymphocytes to adopt a T-cell fate. Importantly, aberrant …
cell homeostasis and is required for lymphocytes to adopt a T-cell fate. Importantly, aberrant …
Deletion-Based Mechanisms of Notch1 Activation In T-ALL: Key Roles for RAG Recombinase and A Conserved Internal Translational Start Site In Notch1.
JC Aster, TD Ashworth, M Chiang, WS Pear… - Blood, 2010 - Elsevier
Abstract 3367 Point mutations that trigger ligand-independent proteolysis of the Notch1
ectodomain occur frequently in human T-cell acute lymphoblastic leukemia (T-ALL) but are …
ectodomain occur frequently in human T-cell acute lymphoblastic leukemia (T-ALL) but are …