Despite over 40 years of research, there is no specific lung-directed therapy for the acute
respiratory distress syndrome (ARDS). Although much has evolved in our understanding of …

It may be hard to argue against the thesis that mechanical ventilation represents one of the
most important treatments ever introduced in the care of patients with respiratory failure …

The pathophysiological mechanisms by which mechanical ventilation can contribute to lung
injury, termed “ventilator-induced lung injury”(VILI), is increasingly well understood.“ …

The supportive care management of the acute respiratory distress syndrome (ARDS) has
remained a cornerstone of therapy in critical care medicine for well over 50 years. Over time …

Protective ventilation strategies for the injured lung currently revolve around the use of low
Vt, ostensibly to avoid volutrauma, together with positive end-expiratory pressure to increase …

Mechanical ventilation can produce lung physiological and morphological alterations
termed ventilator-induced lung injury (VILI). Early experimental studies demonstrated that …

Ventilator-induced lung injury (VILI) results from injury to the blood-gas barrier caused by
mechanical ventilation. The determinants of VILI are more complex than originally thought …

Once upon a time the existence of ventilator-induced lung injury (VILI) was debated. After all,
most patients with lung dysfunction requiring mechanical ventilation had other potential …

Essentially all patients with acute lung injury (ALI) or acute respiratory distress syndrome
(ARDS) require mechanical ventilatory assistance to support gas exchange and reduce the …

Introduction: Mechanical ventilation is required to support respiratory function in the acute
respiratory distress syndrome (ARDS), but it may promote lung damage, a phenomenon …