HDACs (histone deacetylases) 1 and 2 are ubiquitous long-lived proteins, which are often
found together in three major multiprotein co-repressor complexes: Sin3, NuRD …

Abstract Class I Histone deacetylases (HDACs) play a central role in controlling cell cycle
regulation, cell differentiation, and tissue development. These enzymes exert their function …

Class I histone deacetylases (HDACs) are cellular enzymes expressed in many tissues and
play crucial roles in differentiation, proliferation, and cancer. HDAC1 and HDAC2 in …

Histone acetylation regulates chromatin structure and gene expression and is removed by
histone deacetylases (HDACs). HDACs are commonly found in various protein complexes to …

At face value, the Sin3 histone deacetylase (HDAC) complex appears to be a prototypical co-
repressor complex, that is, a multi-protein complex recruited to chromatin by DNA bound …

Histone deacetylases control cellular signaling and gene expression. Histone deacetylase 2
(HDAC2) is crucial for embryonic development, affects cytokine signaling relevant for …

Histone deacetylases (HDACs) are chromatin-modifying enzymes that are involved in the
regulation of proliferation, differentiation and development. HDAC inhibitors induce cell …

Histone deacetylases (HDACs) modulate chromatin structure and transcription, but little is
known about their function in mammalian development. HDAC1 was implicated previously …

Histone deacetylases (HDACs) are part of a vast family of enzymes that have crucial roles in
numerous biological processes, largely through their repressive influence on transcription …

Class I histone deacetylases (HDAC1, HDAC2, and HDAC3) are recruited by cognate
corepressor proteins into specific transcriptional repression complexes that target HDAC …