Control of B cell development through transitional stages in the periphery is critical for the
proper maintenance and selection of mature, functional B cell subsets capable of mediating …

Patients with the immunodeficiency Wiskott-Aldrich syndrome (WAS) frequently develop
systemic autoimmunity. Here, we demonstrate that mutation of the WAS gene results in B …

Wiskott-Aldrich syndrome (WAS) is an X-linked immunodeficiency disorder frequently
associated with systemic autoimmunity, including autoantibody-mediated cytopenias. WAS …

Control of peripheral B cell development and homeostasis depends critically on coordinate
signals received through the BAFFRs and BCRs. The extent to which other signals …

Negative regulation of receptor signaling is essential for controlling cell activation and
differentiation. In B-lymphocytes, the down-regulation of B-cell antigen receptor (BCR) …

Wiskott–Aldrich syndrome (WAS) is a primary immunodeficiency caused by mutations in the
gene encoding the hematopoietic-specific WAS protein (WASp). WAS is frequently …

The Wiskott–Aldrich syndrome (WAS) is an X-linked primary immune deficiency caused by a
mutation in the WAS gene. This leads to altered or absent WAS protein (WASp) expression …

It has long been appreciated that highly autoreactive BCRs are actively removed from the
developing B cell repertoire by Ag-dependent receptor editing and deletion. However, there …

Abstract The Wiskott-Aldrich syndrome protein (WASP) is a key cytoskeletal regulator of
hematopoietic cells. Although WASP-knockout (WKO) mice have aberrant B-cell cytoskeletal …

Over the last decades, research dedicated to the molecular and cellular mechanisms
underlying primary immunodeficiencies (PID) has helped to understand the etiology of many …