Depression is one of the most frequent and severe mental disorder. Since the discovery of
antidepressant (AD) properties of the imipramine and then after of other tricyclic compounds …

Major depressive disorder (MDD) which is supposed to result from a complex interaction of
genetic and epigenetic, environmental and developmental factors is one of the most …

Major depressive disorder is one of the most prevalent and life-threatening forms of mental
illnesses and a major cause of morbidity worldwide. Currently available antidepressants are …

The increasing incidence of depressive spectrum disorders worldwide, together with the
failure of current medication to effectively treat a significant proportion of cases, calls for a …

There is increasing awareness that, in some cases, long-term use of antidepressant drugs
(AD) may enhance the biochemical vulnerability to depression and worsen its long-term …

Depression is a complex and heterogeneous disorder affecting millions of Americans. There
are several different medications and other treatments that are available and effective for …

Genes belonging to neuroplasticity, monoamine, circadian rhythm, and transcription factor
pathways were investigated as modulators of antidepressant efficacy. The present study …

Depression is a devastating disorder that places a significant burden on both the individual
and society. As such, the discovery of novel therapeutics and innovative treatments …

Objective: Major depressive disorder is the most common psychiatric disorder, worldwide,
yet response and remission rates are still unsatisfactory. The identification of genetic …

Most currently available antidepressants target monoamine neurotransmitter function.
However, a purely neurotransmitter-based explanation for antidepressant drug action is …